دراسة مقارنة في تأثير كل من مسحوق بذور الشوفان و عقار السمفستاتين على بعض الهرمونات و الصورة النسجية لأبهر و كبد إناث الأرانب النيوزلندية البيض السليمة و المستأصلة المبايض

Other Title(s)

Comparison study between oat seeds powder and simvastatin drug on some hormones and histological features of aorta and liver in healthy and ovariectomized white female new zealand rabbits

Joint Authors

جانكير، منى حسين
الحديدي، عبير عطا الله عايد
القطان، منتهى محمود داود

Source

Rafidain Journal of Science

Publisher

University of Mosul College of Science

Publication Date

2018-10-31

Country of Publication

Iraq

No. of Pages

16

Main Subjects

Botany

English Abstract

This study was conducted to invistigate the effect of oat seeds powder for which contain of active compounds that stimulate necessary hormones production to reduce the effect of ovariectomy in initiate and development of atherosclerosis, and its effects on liver tissue, then compared with simvastatin drug which used to decrease the level of cholesterol, Triglycerides and (LDL-c) Low Density- Lipoproteins-cholesterol which have the great effect on atherosclerosis.

The results showed positive effects as a significant increase (P≤0.0001) in Adiponectin hormone with significant decrease in Leptin hormone in rabbit's serum that given oat seeds powder and also those treated with simvastatin drug, and insignificant increase in Estrogen hormone in this two groups compared with control group in contrast there is a negative effects as a significant decrease in Adiponectin hormone and Estrogen hormone concentration in ovariectomized rabbit's serum with significant increase in Leptin hormone concentration, while tend in ovariectomized rabbits given oat seeds powder to be in near with normal concentration in control, and ovariectomized rabbits group given simvastatin showed either significant or insignificant near with normal concentration in control.

Experimental atherosclerosis by ovariectomy in females led to negative effects on biochemical criteria of blood serum as compared with control group, which was represented by significant increase in the concentration of Total Cholesterol (TC) and Low Density Lipoprotein-cholesterol (LDL-c), beside significant decrease in High Density Lipoproteinscholesterol (HDL-c) and Paraoxonase enzyme (PON-1), in general treated rabbits with oat seeds powder led to positive willful for all precedent parameters.

Histological sections of aorta artery in ovariectomized rabbits showed atherosclerotic lesions between the muscle fibers in media of aorta in contrast with the normal structure of aorta in rabbits in control group.

Ovaiectomy led to negative effects on histological features of healthy and overectomized rabbit's liver.

Data Type

Conference Papers

Record ID

BIM-902290

• APA
• MLA
• AMA