Angiotensin-converting enzyme (ACE) ID and bradykinin B2 receptor TC genes polymorphism in patients with ACE inhibitors-related cough
Joint Authors
Rohman, Muhammad Saifur
Yunita, Lowry
Fajar, Jonny Karunia
Sidarta, Erdo Puncak
Heriansyah, Teuku
Kuncahyo, Bagus Hery
Saka, Putu Nina Belinda
Widodo, Nashi
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 4 (31 Oct. 2018), pp.307-313, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background: Angiotensin-converting enzyme (ACE) inhibitors-related cough had been reported to contribute for discontinuation of ACE inhibitors therapy.
The role of ACE I/D and bradykinin B2 receptor T/C genes in ACE inhibitors-related cough is still unclear.
Objectives: To determine ACE I/D and bradykinin B2 receptor T/C genes polymorphisms in patients with ACE-inhibitors-related cough.
Subjects and methods: An analytical study with cross-sectional design was conducted at Saiful Anwar General Hospital from June 2013 to September 2014.
We used the polymerase chain reaction to genotype ACE I/D and bradykinin B2 receptor T/C genes.
Data on both ACE I/D and bradykinin B2 receptor T/C genes polymorphisms in cough and non cough group of hypertensive patients treated with ACE inhibitors in our Hospital during the period were analyzed using multiple logistic regression.
Moreover, a metaanalysis was performed to summarize findings from other regions.
Results: A total of 18 patients with cough (21%) and 67 patients without cough (79%) of hypertensive patients treated with ACE inhibitors from our Hospital during the period were analyzed for this study.
In our population, no correlation was observed between ACE inhibitors-related cough and both ACE I/D (p = 0.560) and bradykinin B2 receptor T/C (p = 0.475) genes polymorphism.
However, our meta-analysis of five studies consisting of 267 patients with cough and 346 patients without cough revealed that higher risk of ACE inhibitors-related cough was 1.82-fold associated with T allele of bradykinin B2 receptor T/C gene polymorphism (p = 0.0310).
Conclusions: While the evidence in our meta-analysis suggests strong role for bradykinin gene polymorphism in ACE inhibitors-related cough, however, in our population, we did not find any association.
American Psychological Association (APA)
Rohman, Muhammad Saifur& Fajar, Jonny Karunia& Kuncahyo, Bagus Hery& Yunita, Lowry& Sidarta, Erdo Puncak& Saka, Putu Nina Belinda…[et al.]. 2018. Angiotensin-converting enzyme (ACE) ID and bradykinin B2 receptor TC genes polymorphism in patients with ACE inhibitors-related cough. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 4, pp.307-313.
https://search.emarefa.net/detail/BIM-902396
Modern Language Association (MLA)
Rohman, Muhammad Saifur…[et al.]. Angiotensin-converting enzyme (ACE) ID and bradykinin B2 receptor TC genes polymorphism in patients with ACE inhibitors-related cough. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 4 (Oct. 2018), pp.307-313.
https://search.emarefa.net/detail/BIM-902396
American Medical Association (AMA)
Rohman, Muhammad Saifur& Fajar, Jonny Karunia& Kuncahyo, Bagus Hery& Yunita, Lowry& Sidarta, Erdo Puncak& Saka, Putu Nina Belinda…[et al.]. Angiotensin-converting enzyme (ACE) ID and bradykinin B2 receptor TC genes polymorphism in patients with ACE inhibitors-related cough. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 4, pp.307-313.
https://search.emarefa.net/detail/BIM-902396
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 312-313
Record ID
BIM-902396