Evaluation of some Biochemical parameters in serum patients with thyroid gland dysfunction

Abstract EN

Thyroid gland is one of the most important endocrine glands in the body that regulates a wide array of parameters such as lipid profiles, homocystein and malandialdehyde level.

The present study included 50 patients with thyroid dysfunction and equal number matched healthy control.

The results obtained from the present study, Have reported a significant increase in (TC, TG and LDL) level and significant decrease in level of HDL at (p<0.01) in the Hyperthyroidism patients compared with control.

while in the hyperthyroidism the data in this study show significant decrease in the level of TG and LDL(P<0.01) and increase HDL level at (p<0.01) compared with control.

While No significant difference was shown in TC level in hyperthyroidism.

Furthermore, this study showed high significant for MDA level (p<0.01) in both hypo and hyperthyroidism compared with control .

in this work, there was significantly increased (P<0.01) in serum HOMS in hypothyroidism compared with control, and no significantly in hyperthyroidism.

Moreover , the results showed significant decrease TSH level and significant increase T4 and T3 at (P<0.01) in hyperthyroidism compared with control.

the study has also reported significant elevation for TSH level and significant lower for T4 and T3 at (P<0.01) in hypothyroidism compared with control .

Objective: The present study showed a biochemical relationship between thyroid dysfunction and lipid profiles, homocystein and malandialdehyde .