The association of a rare variant of -93, -53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance
Joint Authors
Mittal, Balraj
Srivastava, Apurva
Awasthi, Shally
Srivastava, Neena
Prakash, Jai
Source
Issue
Vol. 33, Issue 5 (30 Sep. 2018), pp.401-408, 8 p.
Publisher
Publication Date
2018-09-30
Country of Publication
Oman
No. of Pages
8
Main Subjects
Abstract EN
Objectives: Obesity increases the risk of numerous chronic diseases.
Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage.
The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.
We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).
Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR.
Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.
Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR.
Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.
American Psychological Association (APA)
Prakash, Jai& Mittal, Balraj& Srivastava, Apurva& Awasthi, Shally& Srivastava, Neena. 2018. The association of a rare variant of -93, -53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance. Oman Medical Journal،Vol. 33, no. 5, pp.401-408.
https://search.emarefa.net/detail/BIM-902504
Modern Language Association (MLA)
Prakash, Jai…[et al.]. The association of a rare variant of -93, -53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance. Oman Medical Journal Vol. 33, no. 5 (Sep. 2018), pp.401-408.
https://search.emarefa.net/detail/BIM-902504
American Medical Association (AMA)
Prakash, Jai& Mittal, Balraj& Srivastava, Apurva& Awasthi, Shally& Srivastava, Neena. The association of a rare variant of -93, -53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance. Oman Medical Journal. 2018. Vol. 33, no. 5, pp.401-408.
https://search.emarefa.net/detail/BIM-902504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 407-408
Record ID
BIM-902504