The association of a rare variant of -93, -53 promoter gene polymorphisms of lipoprotein lipase gene with obesity and insulin resistance

Abstract EN

Objectives: Obesity increases the risk of numerous chronic diseases.

Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage.

The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity.

We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR).

Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR.

Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism.

Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR.

Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.