Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients
Joint Authors
Kandil, Nuha S.
al-Sharqawi, Raniya Muhammad
Dasuqi, Lubna Muhammad Ibrahim
Qandil, Lamya Said
Masud, I. M.
Amin, Nuha Jabir
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 4 (31 Oct. 2018), pp.379-383, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-10-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: The highly polymorphic gene encoding human renalase (RNLS) is a 311,000 bp gene located on chromosome 10.
Aim: This study aimed at studying the possible association of the two RNLS gene polymorphisms rs2576178 and rs10887800 with chronic kidney disease in general or specifically with hypertensive nephropathy in Egyptian end stage renal disease (ESRD) patients on maintenance hemodialysis.
Subjects and method: This case control study was conducted on two hundred and eighty one individuals, divided equally into two groups; an end stage renal disease patients on maintenance hemodialysis with/ without hypertension and healthy matching individuals as a control group.
Full clinical examination, Biochemical analysis and Molecular genetic testing were performed to detect single nucleotide polymorphism using restriction fraction length polymorphism (RFLP) for RNLS rs2576178 and rs1088780.
Results: The results of this study demonstrated that the risk of developing ESRD was increased among carriers of AA genotype for the rs10887800 (3.05 times) p = 0.001, OR = 3.05, CI95% (1.558–5.971) and GG genotype for the rs2576178 p = 0.047, OR = 1.949, CI95% (1.028–3.694).
Conclusion: Our study revealed that the risk of developing end stage renal diseases was increased among carriers of AA genotype for the rs10887800 polymorphism and GG genotype for the rs2576178 polymorphism.
American Psychological Association (APA)
Kandil, Nuha S.& al-Sharqawi, Raniya Muhammad& Dasuqi, Lubna Muhammad Ibrahim& Qandil, Lamya Said& Masud, I. M.& Amin, Nuha Jabir. 2018. Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 4, pp.379-383.
https://search.emarefa.net/detail/BIM-902595
Modern Language Association (MLA)
Kandil, Nuha S.…[et al.]. Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 4 (Oct. 2018), pp.379-383.
https://search.emarefa.net/detail/BIM-902595
American Medical Association (AMA)
Kandil, Nuha S.& al-Sharqawi, Raniya Muhammad& Dasuqi, Lubna Muhammad Ibrahim& Qandil, Lamya Said& Masud, I. M.& Amin, Nuha Jabir. Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 4, pp.379-383.
https://search.emarefa.net/detail/BIM-902595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 383
Record ID
BIM-902595