Comparative histopathological evaluation of platelet-rich plasma injection and autologous blood injection to temporomandibular joint : a pilot experimental study
Joint Authors
Gulsen, Ugur
Senturk, Muhammad Fatih
Yurtutan, Muhammad Imri
Gulsen, Elif Asli
Bayram, Pınar
Ozdemir, Derya
Erdimli, Isra
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 21, Issue 8 (31 Aug. 2019), pp.1-6, 6 p.
Publisher
Publication Date
2019-08-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : chronic recurrent TMJ dislocation adversely affects patients’ lives.
various surgical and non-surgical methods have been used for treating recurrent TMj dislocation.
some non-surgical methods include physiotherapy, occlusal splint, and avoidance of activities causing large-mouth- opening, and autologous blood or platelet- rich plasma- injection to the temporomandibular joint (TMJ).
Objectives : this experimental study aimed to compare the histopathological evaluation of platelet-rich plasma (PRP) injection and autologous blood (ab) injection to the temporomandibular joint.
Methods : this experimental study was conducted in an animal lab affiliated to the Gazi university of medical sciences, Ankara, turkey, in 2016.
bilateral TMJs from 12 young new Zealand white rabbits were assessed in the study.
the animals were divided into two experimental groups with equal numbers (n = 6) including PRP and ab injection groups.
for the experimental groups, 1mlwas injected into the upper joint space and 0.5 ml to the pericapsular tissue.
the injections were administered unilaterally.
moreover, 1 ml of isotonic saline was injected into the contralateral sides of TMJ upper joint space and 0.5 ml into the pericapsular tissue to serve as controls for both groups.
one month after the experimentation, the animals were sacrificed, and histological analyses were performed for fibrosis and tissue reactions.
Results : collagen fibers and adipose tissue production in the retrodiscal ligament were more in the PRP group than in the ab group.
according to the fibrosis classification, similar fibrotic changes were observed in the ab and PRP-injected tissue samples compared to controls.
no cartilage degeneration was seen in either of the two groups.
Conclusions : considering the limitations of this study, PRP injection may be an alternative to ab injection for treating chronic mandibular dislocation.
clinicians could safely use the PRP injection technique to increase the success rate of the treatment.
American Psychological Association (APA)
Gulsen, Ugur& Senturk, Muhammad Fatih& Yurtutan, Muhammad Imri& Gulsen, Elif Asli& Bayram, Pınar& Ozdemir, Derya…[et al.]. 2019. Comparative histopathological evaluation of platelet-rich plasma injection and autologous blood injection to temporomandibular joint : a pilot experimental study. Iranian Red Crescent Medical Journal،Vol. 21, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-902912
Modern Language Association (MLA)
Gulsen, Ugur…[et al.]. Comparative histopathological evaluation of platelet-rich plasma injection and autologous blood injection to temporomandibular joint : a pilot experimental study. Iranian Red Crescent Medical Journal Vol. 21, no. 8 (Aug. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-902912
American Medical Association (AMA)
Gulsen, Ugur& Senturk, Muhammad Fatih& Yurtutan, Muhammad Imri& Gulsen, Elif Asli& Bayram, Pınar& Ozdemir, Derya…[et al.]. Comparative histopathological evaluation of platelet-rich plasma injection and autologous blood injection to temporomandibular joint : a pilot experimental study. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 8, pp.1-6.
https://search.emarefa.net/detail/BIM-902912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-902912