Effects of vitamin B-complex supplementation alone or combined with estrogen on bone loss in ovariectomized rats

Joint Authors

al-Said, Hanan F.
Shalabi, Azizah B.
Ibrahim, Bassant M. M.

Source

Journal of Medical and Pharmaceutical Sciences

Issue

Vol. 1, Issue 2 (30 Jun. 2017), pp.8-23, 16 p.

Publisher

National Research Center

Publication Date

2017-06-30

Country of Publication

Palestine (Gaza Strip)

No. of Pages

16

Main Subjects

Pharmacology

Abstract EN

Background: Postmenopausal osteoporosis has become a global health issues recently.

Several vitamins play a role in building and maintenance of bones.

Objective: To evaluate the possible roles of vitamin B-complex supplementation alone or combined with estrogen in the improvement of osteoporosis in ovariectomized (OVX) rats.

Materials and Methods: Fifty adult female albino rats were equally divided into 5 groups then 4 groups were exposed to ovariectomy: Control group, OVX group, OVX/ Ethinyl estradiol (EE) group, OVX/B-complex group and OVX/EE/B-complex only.

All treatments were started 4 weeks after surgery and continued for 8 weeks.

Blood samples were collected to measure serum levels of homocysteine (HCY), bone–specific alkaline phosphatase (BAP), collagen type 1 cross-linked C-telopeptide (CTX) and calcium (Ca++).

Results: Ovariectomy increased serum levels of Ca++, bone turnover markers (BAP and CTX) and homocysteine (HCY).

Serum Ca++ levels were increased, while serum levels of bone markers and HCY were decreased) in all treated groups but, only rats treated with EE and vitamin B-complex returned the serum levels of CTX and HCY to normal.

Conclusion: Vitamin B-complex showed some antiosteoporotic effects in OVX rats.

American Psychological Association (APA)

al-Said, Hanan F.& Ibrahim, Bassant M. M.& Shalabi, Azizah B.. 2017. Effects of vitamin B-complex supplementation alone or combined with estrogen on bone loss in ovariectomized rats. Journal of Medical and Pharmaceutical Sciences،Vol. 1, no. 2, pp.8-23.
https://search.emarefa.net/detail/BIM-903136

Modern Language Association (MLA)

al-Said, Hanan F.…[et al.]. Effects of vitamin B-complex supplementation alone or combined with estrogen on bone loss in ovariectomized rats. Journal of Medical and Pharmaceutical Sciences Vol. 1, no. 2 (Jun. 2017), pp.8-23.
https://search.emarefa.net/detail/BIM-903136

American Medical Association (AMA)

al-Said, Hanan F.& Ibrahim, Bassant M. M.& Shalabi, Azizah B.. Effects of vitamin B-complex supplementation alone or combined with estrogen on bone loss in ovariectomized rats. Journal of Medical and Pharmaceutical Sciences. 2017. Vol. 1, no. 2, pp.8-23.
https://search.emarefa.net/detail/BIM-903136

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 17-22

Record ID

BIM-903136