Impact of oocyte morphology on fertilization, embryo quality and pregnancy after ICSI : evaluation with diabetes and PCOS

Abstract EN

Intra-cytoplasmic sperm injection (ICSI) has become an essential procedure in assisted reproductive units for infertile patients.

polycystic ovary syndrome (PCOS) and diabetes are two syndromes having drawbacks on fertility.

the aim of this research is to study the impact of the morphological abnormalities of mii oocytes on fertilization rate, embryo quality and pregnancy following ICSI in patients with diabetes, PCOS patients.

this prospective observational study was conducted on 177 women.

mii oocytes with normal or abnormal morphology, fertilization rate, embryo quality, and positive or negative pregnancies were assessed in all patients and compared between the different groups.

in the control group the total number of oocyte abnormalities was 146/446 mii oocytes representing a percentage of (33%).

in the diabetes group, the total number of abnormalities in mii oocytes was 231/90 mii oocytes representing a percentage of (257%), and in the PCOS group, the total number of abnormalities was 414/229 abnormalities in the mii oocytes representing a percentage of (181%).

in the diabetic patients, despite the higher oocytes abnormalities and the lower quality embryos compared to the PCOS patients, the pregnancy rate was significantly higher in the diabetes group (59.5%) compared to the PCOS group (51.9%), the highest percentage of pregnancy presented in the control group (83.7%).

ICSI outcome was significantly better in the diabetic patients when compared to the PCOS patients.

the best outcome was observed in the control group..