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Synthesis, identification and study the biological activity of some tetrazole derivatives from imidazole derivative
Joint Authors
Source
Journal of Kufa for Chemical Science
Issue
Vol. 2, Issue 2 (30 Jun. 2017), pp.45-64, 20 p.
Publisher
University of Kufa Faculty of Education for Women Department of Chemistry
Publication Date
2017-06-30
Country of Publication
Iraq
No. of Pages
20
Main Subjects
Abstract EN
This research involved synthesis of tetrazol derivatives by a chain of reaction.
The first step includes react between o-phenylenediamin with 5-amino salicylic acid to get 4-amino-2(1H-benzo[d]imidazol-2-yl)phenol(1).(1) react with (4-dimethylamino benzaldehyde ,4-hydroxy acetophenone ,Vanillin, Acetylacetone , 4-Bromoacetophenone and m-aminoacetophenone) to get schiff base derivatives (2,3,4,5,6 and 7) consecutive.(7) react with (4-chlorobenzaldehyde ,4-Bromoacetophenone) to get schiff base derivatives (8,9) consecutive.(1) react with salicylaldehyde and sodium Nitrate in acid medium to get azo derivative (18).All schiff base derivatives (2,3,4,5,6,7,8,9) react with sodium azide to get tetrazol derivatives (10,11,12,13,14,15,16 and17) consecutivly.(18) which react with ( 3-nitro aniline , 4- amino acetophenone , 2-amino-5-nitrothiazole ,2-aminobenzimidazole ,2-aminopyridine and benzidine) to get schiff base derivatives (19,20,21,22,23 and 24) consecutive,which react with sodium azide to get tetrazole derivatives (25,26,27,28,29 and 30) consecutive.All these compounds characterized by means of FT-IR,and some of the compounds by means of 1H-NMR, and13C-NMR and follow the reaction by Rf-TLC and measurement of melting point.
American Psychological Association (APA)
Fadil, Zaynab& Adnan, Shayma. 2017. Synthesis, identification and study the biological activity of some tetrazole derivatives from imidazole derivative. Journal of Kufa for Chemical Science،Vol. 2, no. 2, pp.45-64.
https://search.emarefa.net/detail/BIM-903466
Modern Language Association (MLA)
Fadil, Zaynab& Adnan, Shayma. Synthesis, identification and study the biological activity of some tetrazole derivatives from imidazole derivative. Journal of Kufa for Chemical Science Vol. 2, no. 2 (Jun. 2017), pp.45-64.
https://search.emarefa.net/detail/BIM-903466
American Medical Association (AMA)
Fadil, Zaynab& Adnan, Shayma. Synthesis, identification and study the biological activity of some tetrazole derivatives from imidazole derivative. Journal of Kufa for Chemical Science. 2017. Vol. 2, no. 2, pp.45-64.
https://search.emarefa.net/detail/BIM-903466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 63-64
Record ID
BIM-903466