Preparation, characterization and biological study of new azo-oxime ligand and some of its metal complexes

Abstract EN

New chelate compounds, with general formula [M (HL)2(H2O)2].

when [M= Co(II), Ni(II), and Cu(II)] and [M (HL)2].(H2O)2 for Zn(II) and Cd(II), were prepared by reacting chloride salts of these metal with new azo-oxime ligand 2-Hydroxy(3-trifloromethylphenylazo)-benzaldehydeoxime (H2L), which was prepared by coupling of diazonium salt of 3-Methylanilin with Salicylaldoxime.

The new azo-oxime ligand and its chelate complexes were characterized by available techniques and the results showed that Co(II), Ni(II), and Cu(II)] chelate complexes have octahedral geometry where Zn(II) and Cd(II), have tetrahedral geometry.

The ligand and their metal complexes was tested invitro against the sensitive organisms Staphyllococcus aureus, Streptococcus mutants, Escherichia coli and Proteus mirabilis as antibacterial and Aspergillus flavus, Aspergillus terreus as fungicidal.

The activity data show that the metal complexes higher antibacterial and antifungus activity than the free ligand.