Measurement of interleukine-6 and c-reactive protein in serum of patients on amlodipine therapy

Abstract EN

The aims of this study were to compare between the immunological parameters (serum interleukin-6 (IL-6) and c-reactive protein (CRP) of patients suffering from chronic cardiovascular diseases with amlodipine therapy and control group to determine the effects of the drug on those parameters.

Materials and Methods: The study was conducted on 42 subjects, 27 patients already on amlodipine therapy, aged ranged between 34-75 years.

Fifteen healthy subjects of the same age group participated in this study as a control group.

The screening by medical history, examination (gingival enlargement scores) and blood samples to measure serum IL-6 and CRP was done once at base line visit.

Results: The results obtained showed that amlodipine trherapy group had higher gingival overgrowth scores and immunological parameters than control group with significant difference at (p<0.05), also there was positive correlation but not significant between CRP in serum and IL-6 (p< 0.05).

Conclusion: The study concluded that there is a significant difference in the GO score and immunological parameters in amlodipine therapy group as compared with healthy group.