Treatment of metabolic acidosis in altering inflammatory biomarkers in renal transplant recipients : a randomized clinical trial
Joint Authors
Alirezaei, Amir Husam
Masudi, Nilofar
Bakhtiyari, Mahmud
Fathi, Muhammad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 10 (31 Oct. 2018), pp.1-8, 8 p.
Publisher
Publication Date
2018-10-31
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background: Metabolic acidosis following kidney transplantation can lead to several undesirable effects such as disturbing the protein balance resulting in a negative nitrogen equilibrium, increased protein degradation, and essential amino acid oxidation.
Objectives: The current study aimed tocompare the effect of normal saline as a common crystalloid in kidney transplant surgery to reduce the risk of hyperkalemia and sodium bicarbonate on the metabolic acidosis rate after renal transplantation.
Methods: A total of 40 patients with end-stage renal disease (ESRD) and candidates receiving renal transplant from a living donor referring to the kidney transplantation department of a University affiliated hospital, Tehran, Iran, that meeting the inclusion criteria of this study, were randomly assigned to the intervention group, who were treated with sodium bicarbonate, and the control group, who were treated with normal saline.
The primary outcomes measured in this study were acidosis biomarkers including BE, HCO3, PaCO2, and PH and the secondary outcomes included some inflammatory biomarkers and some renal function biomarkers.
Results: The meanstandard deviation of age in the intervention and control groups was 44.412.4 and 40.013.0, respectively (P = 0.01).
A total of 29 of the participants were male (14 in the intervention group and 15 in the control group), and 11 of them (six in the intervention group and five in the control group) were female.
The meanstandard deviation of change in the concentration of PH, BE, HCO3, and PaCO2 in the intervention and control groups was 0.01 0.1 and -0.08 0.1 (P < 0.001); 0.61 4.2 and -3.8 2.6 (P < 0.001); 0.362.9 and -2.672.1 (P: 0.001); and 0.85.4 and 1.45.3 (P: 0.799), respectively.
Conclusions: The present study revealed that the patients who received sodium bicarbonate had a better status than the normal saline recipients in terms of the maintenance of acid-base homeostasis, inflammatory indexes, and renal function.
American Psychological Association (APA)
Fathi, Muhammad& Masudi, Nilofar& Alirezaei, Amir Husam& Bakhtiyari, Mahmud. 2018. Treatment of metabolic acidosis in altering inflammatory biomarkers in renal transplant recipients : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 10, pp.1-8.
https://search.emarefa.net/detail/BIM-904038
Modern Language Association (MLA)
Fathi, Muhammad…[et al.]. Treatment of metabolic acidosis in altering inflammatory biomarkers in renal transplant recipients : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 10 (Oct. 2018), pp.1-8.
https://search.emarefa.net/detail/BIM-904038
American Medical Association (AMA)
Fathi, Muhammad& Masudi, Nilofar& Alirezaei, Amir Husam& Bakhtiyari, Mahmud. Treatment of metabolic acidosis in altering inflammatory biomarkers in renal transplant recipients : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 10, pp.1-8.
https://search.emarefa.net/detail/BIM-904038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-904038