Comparing the effect of dill seed vaginal cream, with a Persian traditional base, and 1% clotrimazole vaginal cream on vulvovaginal candidiasis : a double-blind, randomized clinical trial
Joint Authors
Sarhadinejad, Zahrah
Tajadini, Halah
Tansaz, Mojgan
Sarhadynejad, Zarrin
Sharififar, Fariba
Iranpour, Maryam
Salari, Zahrah
Bahrampour, Abbas
Ansari, Mehdi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 10 (31 Oct. 2018), pp.1-10, 10 p.
Publisher
Publication Date
2018-10-31
Country of Publication
United Arab Emirates
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background: Vulvovaginal candidiasis (VVC) is a very common debility in gynecology clinics.
Despite access to several antifungal agents, VVC is still a challenge; therefore, presenting a novel antifungal agent, especially with a traditional origin, is of interest and demand.
Objectives: The current study aimed at comparing the efficacy of Anethum graveolens L.
(dill) vaginal cream with that of 1% Clotrimazole vaginal cream to treat VVC.
Methods: A prospective, single-center, randomized, double-blind clinical trial was performed.
In the current study, married females aged 18 - 65 years, with probable vulvovaginal candidiasis were enrolled for primary evaluation.
After VVC confirmation by the sniff test, the patients were allocated into three groups with regard to blocked randomization, and inclusion and exclusion criteria.
The first group (n = 59) was treated with 1% Clotrimazole vaginal cream; the second (n = 60) with a combination of dill seed essential oil and dried aqueous extract vaginal cream (TEE); and the last (n = 56) with dill seed essential oil vaginal cream (EO) for seven nights.
After 10 days, the therapeutic effects were assessed.
Results: After the intervention, itching decreased to 30.5%, 3.3%, and 12.5% in the Clotrimazole, TEE, and EO groups, respectively; the sniff test also decreased to 33.9%, 13.3%, and 12.5%, respectively.
Although a statistically significant difference, according to itching and sniff test, was observed among the three groups (P < 0.001, P = 0.005), there was no significant difference between TEE and EO (P = 0.06).
Conclusions: The current study showed that the herbal preparation could be used as an alternative antifungal agent for vulvovaginal Candidiasis.
American Psychological Association (APA)
Sarhadinejad, Zahrah& Tajadini, Halah& Tansaz, Mojgan& Bahrampour, Abbas& Sarhadynejad, Zarrin& Ansari, Mehdi…[et al.]. 2018. Comparing the effect of dill seed vaginal cream, with a Persian traditional base, and 1% clotrimazole vaginal cream on vulvovaginal candidiasis : a double-blind, randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 10, pp.1-10.
https://search.emarefa.net/detail/BIM-904046
Modern Language Association (MLA)
Sarhadinejad, Zahrah…[et al.]. Comparing the effect of dill seed vaginal cream, with a Persian traditional base, and 1% clotrimazole vaginal cream on vulvovaginal candidiasis : a double-blind, randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 10 (Oct. 2018), pp.1-10.
https://search.emarefa.net/detail/BIM-904046
American Medical Association (AMA)
Sarhadinejad, Zahrah& Tajadini, Halah& Tansaz, Mojgan& Bahrampour, Abbas& Sarhadynejad, Zarrin& Ansari, Mehdi…[et al.]. Comparing the effect of dill seed vaginal cream, with a Persian traditional base, and 1% clotrimazole vaginal cream on vulvovaginal candidiasis : a double-blind, randomized clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 10, pp.1-10.
https://search.emarefa.net/detail/BIM-904046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-904046