Osseous involvement of langerhans cellhistiocytosis in childhood : case reports

Abstract FRE

Langerhans cell histiocytosis (LCH) is a rare disease arising from clonal proliferation of Langerhans cells, affecting predominantly children.

It can take many forms, from a single eosinophilic granuloma to widespread lesions involving multiple systems and might be life-threatening.

Bone is the most common organ involved; osseous involvement can be uni- or multifocal.

We report two cases: a multifocal osseous Langerhans cell histiocytosis involving the 9th left rib, vertebral body of T1 and the left iliac bone; and a unifocal osseous Langerhans cell histiocytosis involving the right femur.

Biopsy established the diagnosis in correlation with radiology.

The patients received chemotherapy and steroids.

Outcome was favorable on follow-up.