Saffron (Crocus sativus L.) supplements modulate circulating MicroRNA (miR-21) in atherosclerosis patients : a randomized, double-blind, placebo-controlled trial
Joint Authors
Ostadrahimi, Ali Rida
Barzegari, Abu al-Fadl
Khatir, Shunaz Ahmadi
Bayatian, Ayat Allah
Roshanravan, Nida
Sufyan, Abd al-Rasul
Pavon Djavid, Graciela
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 10 (31 Oct. 2018), pp.1-11, 11 p.
Publisher
Publication Date
2018-10-31
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Abstract EN
Background: microRNAs (miRNAs) are endogenous gene expression regulators, which are involved in the physiopathology of diseases, and potentially make biomarkers in diseases, such as Cardiovascular Disease (CVD).
Objectives: Since miR-21 is a robust regulator in plaque formation, this studyaimed at identifying the effect of saffron as a functional food and traditional food additive antioxidant in fighting against the progress of atherosclerosis, by modulation of miR-21, as a new circulating marker of inflammation.
Methods: In this randomized, double-blind clinical trial, 63 subjects with atherosclerosis were recruited from Emam Sajjad Hospital, Valiasr Hospital, and Zafaranieyh Clinic in Tehran, Iran, and divided randomly to two groups.
They received 100 mg/d saffron or a placebo capsule for six weeks.
The expression levels of miR-21 were quantified by real-time quantitative-PCR (RT-qPCR) in the blood of patients.
Furthermore, fasting blood sugar, lipid profile, and anthropometric index of participants were evaluated before and after the intervention.
Results: Statistical analysis showed significant differences in the expression level of miR-21 between atherosclerosis patients, who received placebo, and those, who consumed saffron (P value = 0.02).
Moreover, a significant decrease was seen in hip circumference after saffron supplementation (P = 0.049, P = 0.006).
Nevertheless, consumption of saffron did not significantly influence other anthropometric indexes and blood biochemical parameters, such as FBS and lipid profile.
Conclusions: In the present study, different expression levels of miR-21 were observed between patients with atherosclerosis, who received saffron supplements and placebo; thus saffron may be considered as a novel therapeutic target in cardiovascular disease management.
American Psychological Association (APA)
Khatir, Shunaz Ahmadi& Bayatian, Ayat Allah& Barzegari, Abu al-Fadl& Roshanravan, Nida& Sufyan, Abd al-Rasul& Pavon Djavid, Graciela…[et al.]. 2018. Saffron (Crocus sativus L.) supplements modulate circulating MicroRNA (miR-21) in atherosclerosis patients : a randomized, double-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 10, pp.1-11.
https://search.emarefa.net/detail/BIM-904089
Modern Language Association (MLA)
Khatir, Shunaz Ahmadi…[et al.]. Saffron (Crocus sativus L.) supplements modulate circulating MicroRNA (miR-21) in atherosclerosis patients : a randomized, double-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal Vol. 20, no. 10 (Oct. 2018), pp.1-11.
https://search.emarefa.net/detail/BIM-904089
American Medical Association (AMA)
Khatir, Shunaz Ahmadi& Bayatian, Ayat Allah& Barzegari, Abu al-Fadl& Roshanravan, Nida& Sufyan, Abd al-Rasul& Pavon Djavid, Graciela…[et al.]. Saffron (Crocus sativus L.) supplements modulate circulating MicroRNA (miR-21) in atherosclerosis patients : a randomized, double-blind, placebo-controlled trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 10, pp.1-11.
https://search.emarefa.net/detail/BIM-904089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-11
Record ID
BIM-904089