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Rituximab treatment in myasthaenia gravis : report of two paediatric cases
Other Title(s)
العلاج بعقار الريتوكسيماب في الوهن العضلي الشديد : تقرير عن طفلين مصابين
Joint Authors
Abd al-Rahim, Rana
al-Futaisi, Amnih
Koul, Roshan
Abdwani, Rim
al-Asimi, Abd Allah
Mani, Renjith
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 18, Issue 2 (31 May. 2018), pp.223-227, 5 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2018-05-31
Country of Publication
Oman
No. of Pages
5
Main Subjects
Abstract EN
Myasthaenia gravis (MG) is an autoimmune disease involving the postsynaptic receptors in the neuromuscular junction.
The condition is characterised by fatigable weakness of the skeletal muscles and is uncommon in children.
Acetylcholinesterase inhibitors and immune-modifying medications are usually considered the mainstay of treatment.
However, these medications have to be given on a lifelong basis so that patients remain in remission; furthermore, drug-related side-effects can have a major impact on quality of life.
We report two paediatric cases who were treated for MG at the Sultan Qaboos University Hospital, Muscat, Oman, in 2007 and 2008, respectively.
Rituximab was eventually administered to each patient after their condition failed to improve despite several years of standard treatment with acetylcholinesterase inhibitors and immune-modifying medications.
Overall, rituximab resulted in complete remission in one case and significant clinical improvement in the other case.
American Psychological Association (APA)
Koul, Roshan& al-Futaisi, Amnih& Abd al-Rahim, Rana& Mani, Renjith& Abdwani, Rim& al-Asimi, Abd Allah. 2018. Rituximab treatment in myasthaenia gravis : report of two paediatric cases. Sultan Qaboos University Medical Journal،Vol. 18, no. 2, pp.223-227.
https://search.emarefa.net/detail/BIM-904228
Modern Language Association (MLA)
Koul, Roshan…[et al.]. Rituximab treatment in myasthaenia gravis : report of two paediatric cases. Sultan Qaboos University Medical Journal Vol. 18, no. 2 (May. 2018), pp.223-227.
https://search.emarefa.net/detail/BIM-904228
American Medical Association (AMA)
Koul, Roshan& al-Futaisi, Amnih& Abd al-Rahim, Rana& Mani, Renjith& Abdwani, Rim& al-Asimi, Abd Allah. Rituximab treatment in myasthaenia gravis : report of two paediatric cases. Sultan Qaboos University Medical Journal. 2018. Vol. 18, no. 2, pp.223-227.
https://search.emarefa.net/detail/BIM-904228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 226-227
Record ID
BIM-904228