Correlation between chronic tramadol administration and disturbances activity ovarian follicles and endometrium in female rats
Other Title(s)
العلاقة بين التعرض المزمن لعقار الترامادول و حدوث اضطراب في نشاط جريبات المبيض و الرحم في أنثى الفئران
Joint Authors
Muhammad, Mustafa Abd al-Munim
al-Sayyid, Mahmud Hemy
Abu Barakah, Walid Izzat
Mandour, Isam Muhammad rajab
Source
Journal of Medical and Pharmaceutical Sciences
Issue
Vol. 2, Issue 2 (30 Jun. 2018), pp.40-56, 17 p.
Publisher
Publication Date
2018-06-30
Country of Publication
Palestine (Gaza Strip)
No. of Pages
17
Main Subjects
Sociology and Anthropology and Social Work
Abstract EN
Researchers on toxic effects of tramadol on female reproductive system are limited and need to be extended for more confirmations and results So the purpose of this study was to detect the possible correlation between chronic tramadol administration and disturbances activity of ovarian follicles and endometrium in female rats.
The study was involved twentyfive adult female rats divided into 4 experimental groups(A, B, C&D); received tramadol by different doses and methods and control group (CON) received normal saline.
Histopathological examination was done for ovaries and uterus to all groups.
The result in group A showing mild and moderate decreased number of growing follicles and ovulated oocytes with cystic changes and hyper cellular stroma with recovery in 80% in group C.
In group B showing moderate and severe decreased of ovulation with recovery in 40% of growing follicles in group C.
Also in group A showing moderate atrophied endometrial gland with obvious recovery in the group C.
While in group B showing severe atrophy of endometrial gland with recovery in 60 % in group D.
In conclusion; positive correlation between chronic tramadol administration and disturbances activity of ovarian and growing follicles in female rats.
which is not permanent as it can be reversed after withdrawal of the tramadol.
It is recommended that; clinical studies are needed to approve present results about the effect of tramadol on male and female genital system
American Psychological Association (APA)
Muhammad, Mustafa Abd al-Munim& al-Sayyid, Mahmud Hemy& Abu Barakah, Walid Izzat& Mandour, Isam Muhammad rajab. 2018. Correlation between chronic tramadol administration and disturbances activity ovarian follicles and endometrium in female rats. Journal of Medical and Pharmaceutical Sciences،Vol. 2, no. 2, pp.40-56.
https://search.emarefa.net/detail/BIM-904754
Modern Language Association (MLA)
Muhammad, Mustafa Abd al-Munim…[et al.]. Correlation between chronic tramadol administration and disturbances activity ovarian follicles and endometrium in female rats. Journal of Medical and Pharmaceutical Sciences Vol. 2, no. 2 (Jun. 2018), pp.40-56.
https://search.emarefa.net/detail/BIM-904754
American Medical Association (AMA)
Muhammad, Mustafa Abd al-Munim& al-Sayyid, Mahmud Hemy& Abu Barakah, Walid Izzat& Mandour, Isam Muhammad rajab. Correlation between chronic tramadol administration and disturbances activity ovarian follicles and endometrium in female rats. Journal of Medical and Pharmaceutical Sciences. 2018. Vol. 2, no. 2, pp.40-56.
https://search.emarefa.net/detail/BIM-904754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 54-56
Record ID
BIM-904754