Clinical Utility of promoter methylation of the tumor suppressor genes DKK3, and RASSF1A in breast cancer patients
Joint Authors
Said, Marwa H.
Radi, Aya Sami
Abu al-Naja, Jalal Mustafa
Sharqi, Ula A.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 2 (30 Apr. 2018), pp.87-90, 4 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background: DNA methylation is the commonest known epigenetic change that results in silencing of tumor suppressor genes.
Promoter methylation of tumor suppressor genes has the potential for early detection of breast cancer.
Aim: Aim is to examine the potential usefulness of blood based methylation specific polymerase chain reaction (MSP) of methylated DKK3 and RASSF1A genes in early detection of breast cancer.
Method: Methylation status of DKK3 and RASSF1 was investigated in forty breast cancer patients, twenty fibroadenoma patients and twenty healthy ladies as control group using MSP.
Results: Methylation of DKK3 promoter was found in 22.5% of breast cancer patients, while DKK3 methylation was absent in both fibroadenoma patients and control group.
Similarly, methylation of RASSF1 promoter was found in 17.5% of breast cancer patients and in none of fibroadenoma and control group.
Conclusion: Promoter methylation of DKK3 and RASSF1 was found in breast cancer patients while absent in control group suggesting that tumorspecific methylation of the two genes (DKK3 and RASSF1A) might be a valuable biomarker for the early detection of breast cancer.
American Psychological Association (APA)
Said, Marwa H.& Radi, Aya Sami& Abu al-Naja, Jalal Mustafa& Sharqi, Ula A.. 2018. Clinical Utility of promoter methylation of the tumor suppressor genes DKK3, and RASSF1A in breast cancer patients. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 2, pp.87-90.
https://search.emarefa.net/detail/BIM-905694
Modern Language Association (MLA)
Said, Marwa H.…[et al.]. Clinical Utility of promoter methylation of the tumor suppressor genes DKK3, and RASSF1A in breast cancer patients. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 2 (Apr. 2018), pp.87-90.
https://search.emarefa.net/detail/BIM-905694
American Medical Association (AMA)
Said, Marwa H.& Radi, Aya Sami& Abu al-Naja, Jalal Mustafa& Sharqi, Ula A.. Clinical Utility of promoter methylation of the tumor suppressor genes DKK3, and RASSF1A in breast cancer patients. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 2, pp.87-90.
https://search.emarefa.net/detail/BIM-905694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 90
Record ID
BIM-905694