Effect of nanoparticles and x-ray (2-20)‎ MeV on sensitivity enhancement ratio in brain malignant cells

Abstract EN

The importance of this research is to reduce the number of radiotherapy sessions that are given to patients with brain cancer then result in reducing the side effects of radiation therapy.

This is done by increasing sensitivity enhancement ratio (SER).

SER is the ratio of survival cells to initial cells for irradiation without and with nanoparticles.

The direct injection of nanoparticles into brain tumor considered a perfect method to increase (SER).

In this study gold, gadolinium, silver and titanium nanoparticles were used as radio-sensitizing agents to increase (SER).

The contrast agent loaded to brain tumor interacts with x-ray photons whose energy ranged from 2MeV to 20 MeV This led to enhance brain radio-sensitivity by increasing the absorbed dose due to the presence of high absorption coefficient elements.

In this research, we get a percentage of SER from 11.63 to 14.26 depending on the type of contrast agent.