The association of iron and Vitamin B12 status with coronary artery disease in Gaza city

Other Title(s)

العلاقة بين حالة الحديد و فيتامين ب12 مع مرض الشريان التاجي في مدينة غزة

Dissertant

Shamallakh, Khulud Muhammad Hamid

Thesis advisor

al-Zaharinah, Mazin Midhat

University

Islamic University

Faculty

Faculty of Health Sciences

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2019

English Abstract

Background: Coronary artery disease (CAD) is an accumulation of atheromatous plaque in medium and large-sized arteries supplying the myocardium.

Iron plays a key role in the maintenance of different cellular functions and mediates various metabolic processes.

Iron overload would increase CAD risk by promoting lipid peroxidation.

Vitamin B12 acts as a co-factor for the methionine synthase enzyme that catalyzes the conversion of homocysteine to methionine.

The lack of vitamin B12 may raise the concentration of homocysteine in plasma which lead to atherosclerosis.

Knowledge of the relationship between iron status, vitamin B12 and CAD may contribute to setting priorities and establishing effective national prevention programs to decrease morbidity and mortality from CAD.

Objective: To investigate the association of iron and vitamin B12 status with coronary artery disease in Gaza city.

Methodology: Case control study was conducted on a sample of 80 persons aged between 30 to 60 years, 40 in each group i.e.

patients with CAD and apparently healthy controls.

Questionnaire interviews were performed among the study population.

Serum ferritin and vitamin B12 were determined using ELISA kits.

Serum iron, lipid profile parameters, high sensitivity C reactive protein (hs-CRP) were determined chemically.

Low destiny lipoprotein (LDL), and body mass index (BMI) were calculated.

Complete blood count (CBC) was also performed.

An approval was acquired from local ethical committee to perform this study.

All data were analyzed by a computer using SPSS program (version 22).

Results: The results showed that the mean level of serum iron in the male cases (71.6  24.7 µg/dl) was lower compared to that of male controls (87.3  28.4 µg/dl) and the difference was statistically significant.

Moreover, transferrin saturation percentage in male cases (24.0 ± 8.9%) was lower compared to male controls (29.0 ± 9.9%) and the difference was statistically significant (p = 0.045).

Additionally, the mean levels of serum vitamin B12 in male cases (238.8 ± 51.4 pg/dl) was lower compared to male controls (337.3± 108.4 pg/dl) and was statistically significant (p<0.001).

The Pearson correlation test showed there was a significant positive correlation between the level of serum iron with the level of vitamin B12 among males but not females (r = 0.28, p = 0.032).

Conclusions: The mean difference of transferrin saturation and serum ferritin between the male cases and male controls was statistically significant.

In contrast, they were no significant difference among female cases and female controls.

The mean levels of serum vitamin B12 in male cases was lower compared to male controls and was statistically significant.

While, the difference was not statistically significant between female cases and female controls.

Main Subjects

Pharmacy, Health & Medical Sciences

Topics

• Gaza Strip
• Iron
• coronary artery
• Vitamin B12

No. of Pages

102

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-906205