Vitamin D level in gestational diabetic patients from Gaza Strip

Other Title(s)

مستوى فيتامين د عند النساء المصابات بسكري الحمل من قطاع غزة

Dissertant

Nassar, Zayn al-Din Ahmad Muhammad

Thesis advisor

al-Zaharinah, Mazin Midhat

University

Islamic University

Faculty

Faculty of Health Sciences

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2018

English Abstract

Background: Gestational diabetes mellitus (GDM) is described as glucose intolerance of variable intensities that begins or is first diagnosed during pregnancy.

Vitamin D is a fat-soluble vitamin that plays an essential role in calcium homeostasis and the maintenance of normal function in multiple tissues.

In Gaza strip vitamin D deficiency remains a common problem among pregnant women.

During pregnancy low concentration of serum vitamin D is a dangerous sign and can lead to several complications.

Knowledge of the relationship between vitamin D and GDM could lead to new indicators for earlier treatment of cases with GDM, appropriate management to minimize prenatal deaths and to improve the quality of life among both mother and child.

Objective: To assess vitamin D status among GDM pregnant women and its relationship with some biochemical variables in Gaza strip.

Materials and methods: this case control study comprised 45 GDM pregnant women and 45 apparently healthy pregnant women.

Questionnaire interviews were applied among the study population.

Serum vitamin D and insulin levels were measured by ELISA, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), triglycerides, cholesterol, high density lipoprotein (HDL), phosphorus and calcium were determined chemically.

Blood pressure was also measured.

Body mass index (BMI) and low density lipoprotein (LDL) were calculated.

An approval was acquired from local ethical committee to perform this study.

All data were analyzed by a computer using SPSS program.

Results: the average of vitamin D in GDM cases (29.6±10.6 ng/ml) was lower than that in controls (34.5±10.6 ng/ml), the difference was statistically significance (P = 0.031).

There was an increase in the average of FBG, oral glucose tolerance test (OGTT), HbA1c and insulin levels in GDM cases (105.8±15.8 mg/dl), (187±25.5 mg/dl), (7.1±0.4%), (20.4±8.4 µIU/ml), versus controls (66.5±8.1 mg/dl), (85.8±8 mg/dl), (4.4±0.4%), (6.2±1.7 µIU/ml) respectively with (P < 0.001).

Pearson correlation test showed a significant negative correlation between vitamin D and the parameters: weight (r = - 0.251, P = 0.017), BMI (r = -0.223,P=0.035), glucose (r = - 0.235, P = 0.026), OGTT (r = -0.249, P = 0.018) , HbA1c(r = - 0.232, P = 0.028), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (r = -0.215, P = 0.042) and phosphorus (r = -0.401, P < 0.001).

On the other hand, Pearson correlation test showed a significant positive correlation between vitamin D and calcium (P < 0.001).

Conclusions: Vitamin D was lower in GDM women compared to controls in Gaza Strip.

Low vitamin D status may be associated with insulin resistance and act as a risk factor for GDM

Main Subjects

Medicine

Topics

• Pregnancy
• Pregnant woman
• Vitamin D
• Diabetes
• Gaza Strip
• Complications(Medicine)

No. of Pages

89

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-906209