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Assessment of mutagenic and antimutagenic effects of honey formed by innovative way against cyclophosphamid induced chromosomal aberrations in bone marrow cells
Other Title(s)
تقييم التأثير التطفيرى و المضاد للتتطفر للعسل المنتج بطريقة مبتكرة ضد عقار السيكلوفوسفاميد المحفز للتغيرات الكروموسومية في خلايا نخاع العظم للفئران
Joint Authors
Farhan, Ikhlas Muhammad
Jijan, Raqiba Ali
Source
The Iraqi Journal of Agricultural Science
Issue
Vol. 50, Issue 5 (31 Oct. 2019), pp.1336-1344, 9 p.
Publisher
University of Baghdad College of Agriculture
Publication Date
2019-10-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
The present study has been done to assess the mutagenic and antimutagenic effects of honey formed by innovative way (HW) in comparison with two honey formed by different feed sources ; nectar of flowers (HF) and sugar syrup (HS), against the cytotoxity and genotoxicity induced by cyclophosphamide (CP) in mice bone marrow cells ,which was evaluated using chromosomal aberration (CA).
This search was carried out through two stages.
In the first stage, mice were orally treated daily with phosphate buffer saline (PBS) as negative control group, and the other three groups were orally treated daily with two doses of the three types of honey (300 and 600 mg/kg) for 7 and 14 days in order to test the clastogenetic effects of the honey,In the second stage, interactions between the ideal dose (300 mg/kg) of each type of honey and the CP were used for 7 and 14 days in order to test the protective effects of honey formed by innovative way as compard to the other types of honey.
The results of the first experiment indicated that the three types of honey has no significant clastogenetic effects on chromosomal aberrations of the bone marrow cells of treated mice.
The results of the second experiment was showed that (HW) , especially at the ideal dose (300 mg/kg b.w.) exhibited a well protective and high anti-clastogenic efficiency against the genotoxic actions of the cyclophosphamide (CP) on bone marrow cells, by reduce CA frequencies.
American Psychological Association (APA)
Farhan, Ikhlas Muhammad& Jijan, Raqiba Ali. 2019. Assessment of mutagenic and antimutagenic effects of honey formed by innovative way against cyclophosphamid induced chromosomal aberrations in bone marrow cells. The Iraqi Journal of Agricultural Science،Vol. 50, no. 5, pp.1336-1344.
https://search.emarefa.net/detail/BIM-909938
Modern Language Association (MLA)
Farhan, Ikhlas Muhammad& Jijan, Raqiba Ali. Assessment of mutagenic and antimutagenic effects of honey formed by innovative way against cyclophosphamid induced chromosomal aberrations in bone marrow cells. The Iraqi Journal of Agricultural Science Vol. 50, no. 5 (2019), pp.1336-1344.
https://search.emarefa.net/detail/BIM-909938
American Medical Association (AMA)
Farhan, Ikhlas Muhammad& Jijan, Raqiba Ali. Assessment of mutagenic and antimutagenic effects of honey formed by innovative way against cyclophosphamid induced chromosomal aberrations in bone marrow cells. The Iraqi Journal of Agricultural Science. 2019. Vol. 50, no. 5, pp.1336-1344.
https://search.emarefa.net/detail/BIM-909938
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-909938