The genetic association study of TP53 polymorphisms in Saudi obese patients
Shaik, Nur Ahmad
Muhammad, Arif A.
Umar, Abd al-Qadir M. Shaykh
al-Harbi, Muna G.
al-Umari, Abd al-Fattah
Hajrah, Nahid H.
Awan, Zuhayr A.
al-Habashi, Allawi M.
Jansen, Robert K.
Sabir, Jamal S. M.
Country of Publication
No. of Pages
Obesity is a multifactorial metabolic disorder characterized by low grade chronic inflammation.
Rare and novel mutations in genes which are vital in several key pathways have been reported to alter the energy expenditure which regulates body weight.
The TP53 or p53 gene plays a prominent role in regulating various metabolic activities such as glycolysis, lipolysis, and glycogen synthesis.
Recent genome-wide association studies reported that tumor suppressor gene p53 variants play a critical role in the predisposition of type 2 diabetes and obesity.
Till date, no reports are available from the Arabian population; hence the present study was intended to assess the association between p53 variants with risk of obesity development in the Saudi population.
We have selected three p53 polymorphisms, rs1642785 (C > G), and rs9894946 (A > G), and rs1042522 (Pro72Arg; C > G) and assessed their association with obesity risk in the Saudi population.
Phenotypic and biochemical parameters were also evaluated to check their association with p53 genotypes and obesity.
Genotyping was carried out on 136 obese and 122 normal samples.
We observed that there is significantly increased prevalence p52 Pro72Arg (rs1042522) polymorphism in obese persons when compared to controls at GG genotype in overall comparison (OR: 2.169, 95% CI: 1.086-4.334, p = 0.02716).
Male obese subjects showed three-fold higher risk at GG genotype (OR: 3.275, 95% CI: 1.230-8.716, p = 0.01560) and two-fold risk at G allele (OR: 1.827, 95% CI: 1.128-2.958, p = 0.01388) of p53 variant Pro72Arg respectively.
This variant has also shown significant influence on cholesterol, LDL level, and random insulin levels in obese subjects (p ≤ 0.05).
In conclusion, p53 Pro72Arg variant is highly prevalent among obese individuals and may act as a genetic modifier for obesity development among Saudis.
American Psychological Association (APA)
Sabir, Jamal S. M.& al-Umari, Abd al-Fattah& Shaik, Nur Ahmad& Banaganapalli, Babajan& Hajrah, Nahid H.& Zrelli, Huda…[et al.]. 2019. The genetic association study of TP53 polymorphisms in Saudi obese patients. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1338-1343.
Modern Language Association (MLA)
Sabir, Jamal S. M.…[et al.]. The genetic association study of TP53 polymorphisms in Saudi obese patients. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1338-1343.
American Medical Association (AMA)
Sabir, Jamal S. M.& al-Umari, Abd al-Fattah& Shaik, Nur Ahmad& Banaganapalli, Babajan& Hajrah, Nahid H.& Zrelli, Huda…[et al.]. The genetic association study of TP53 polymorphisms in Saudi obese patients. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1338-1343.
Includes bibliographical references : p. 1342-1343