Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats
Joint Authors
Muhammad, Altaf
Kodidhela, Lakshmi Devi
Sammeturi, Manjunatha
Shaik, Althaf Husayn
Bongu, Sasi Bhusana Rao
Cheemanapalli, Srinivasulu
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1429-1435, 7 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objective To evaluate the cardio-protection of syringic acid (SA) in combination with resveratrol (RV) in isoproterenol (ISO) induced myocardial infarcted (MI) rats.
Methods Groups of all rats were subjected oral pre-treatment at the beginning of the study with SA (50 mg/kg), RV (50 mg/kg) and combination (COMB) of SA (25 mg/kg) and RV (25 mg/kg) along with gallic acid (GA) (50 mg/kg) for 30 days.
After sacrification, homogenate of heart tissue along with serum were utilized for further biochemical investigations.
The effects on creatine kinase (CK), aspartate transaminase (AST), alanine transaminase (ALT) and gamma glutamyl transferase (GGT) were studied in serum and heart tissues.
Glutathione-s-transferase (GST), glutathione peroxidase (GPX) and reduced glutathione (GSH), membrane bound enzymes and electrolytes were tested in heart tissues.
Body weights and heart weights were also observed along with high sensitivity C-reactive protein (hs-CRP), uric acid and total protein content (TPC) in serum.
Results CK, AST, ALT and GGT levels in serum were augmented significantly while these enzymes are decreased in cardiac tissue samples of ISO–treated rats.
GST, GPX, GSH, Na+/K+, Mg2+, Ca2+ ATPases, K+ ions were significantly decreased while Na+ and Ca2+ ions were increased in the heart tissues of ISO-injected rats.
Loss and gain of body and heart weights were noticed significantly in rats having ISO administration.
ISO group showed significant increase in hs-CRP and Uric acid while significant decrease in TPC.
All of actions of ISO were ameliorated by COMB.
Conclusions COMB suppressed ISO induced MI in rats and exhibited cardio-protection.
American Psychological Association (APA)
Sammeturi, Manjunatha& Shaik, Althaf Husayn& Bongu, Sasi Bhusana Rao& Cheemanapalli, Srinivasulu& Muhammad, Altaf& Kodidhela, Lakshmi Devi. 2019. Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1429-1435.
https://search.emarefa.net/detail/BIM-909993
Modern Language Association (MLA)
Sammeturi, Manjunatha…[et al.]. Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1429-1435.
https://search.emarefa.net/detail/BIM-909993
American Medical Association (AMA)
Sammeturi, Manjunatha& Shaik, Althaf Husayn& Bongu, Sasi Bhusana Rao& Cheemanapalli, Srinivasulu& Muhammad, Altaf& Kodidhela, Lakshmi Devi. Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1429-1435.
https://search.emarefa.net/detail/BIM-909993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1435
Record ID
BIM-909993