Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network
Joint Authors
Yang, Hong
Liu, Chunyang
Xu, Yanhua
Zhang, Jianhua
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 8 (31 Dec. 2019), pp.1922-1926, 5 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Information Technology and Computer Science
Topics
Abstract EN
Objective: To establish an axon regeneration regulatory network for optimal selection, and explore the role of low intensity pulsed ultrasound in the network.
Methods: The axon regeneration regulatory network involving axon regeneration-related proteins NGF, BDNF and PirB was constructed by using GO and KEGG.
The maximum possible pathway acting on axon regeneration was screened by Bayesian network theory.
The node of low - intensity pulsed ultrasound in NGF - involved axon regeneration network was complemented by combining literature methods.
Results: The NGF, BDNF and PirB-involved axonal regeneration regulatory pathway was successfully constructed.
The low intensity pulsed ultrasound played a role in axon regeneration by acting on ERK1/2- CREB pathway and GSK-3b.
NGF-TrKA-Rap1-ERK1/2-CREB-Bcl-2 was optimized as optimal pathway by Bayesian theory.
Conclusion: The regulatory pathway of axon regeneration involving nerve growth related factors and low intensity pulsed ultrasound was initially established, which provided a theoretical basis for further study of axon regeneration, and also new ideas for action of low intensity pulsed ultrasound on axon regeneration regulatory pathway.
American Psychological Association (APA)
Xu, Yanhua& Yang, Hong& Zhang, Jianhua& Liu, Chunyang. 2019. Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.1922-1926.
https://search.emarefa.net/detail/BIM-910087
Modern Language Association (MLA)
Liu, Chunyang…[et al.]. Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.1922-1926.
https://search.emarefa.net/detail/BIM-910087
American Medical Association (AMA)
Xu, Yanhua& Yang, Hong& Zhang, Jianhua& Liu, Chunyang. Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.1922-1926.
https://search.emarefa.net/detail/BIM-910087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1926
Record ID
BIM-910087