The significance of combined detection of CysC, urinary mAlb and b2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome

Joint Authors

Zhang, Lin
Zhang, Ming
Sun, Jin
Mai, Weitu
Yin, Zhiping
Le, Fang
Fang, Xiang
Lin, Yun

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.1982-1985, 4 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

4

Main Topic

Diseases

Topics

Abstract EN

Objective: To elaborate the significance of combined detection of cystatin C, urinary micro-albumin (mAlb) and b2-microglobulin (b2-MG) in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome.

Methods: A total of 120 patients with pregnancy-induced hypertension syndrome who were admitted to this hospital for treatment between November 2015 and October 2018 were enrolled as subjects, and divided into the control group (without complication of renal injury, n = 76) and the observation group (with complication of renal injury, n = 44) according to the complications of early renal injury.

Furthermore, 60 patients who participated in the antenatal care in this hospital were enrolled as the normal subjects (normal group).

Automatic biochemistry analyzer was utilized to measure CysC, urinary mAlb and b2-MG in serum to evaluate the specificity, sensitivity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of single or combined measurements of these indexes in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome.

Results: In the observation group, the levels of CysC, urinary mAlb and b2-MG were higher than those in the control group, while the levels in the normal group were the lowest (P < 0.05).

Combined measurement of CysC, urinary mAlb and b2-MG showed a higher accuracy (90.0%) in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome than the single measurements, and the difference had statistical significance (P < 0.05).

Besides, the sensitivity, specificity, PPV and NPV of the combined measurements were 94.59%, 87.30%, 81.40% and 94.49%, slightly higher than the single measurements, with no statistical significance in differences (P > 0.05).

Conclusion: CysC, urinary mAlb and b2-MG can reflect the renal injury effectively, and the combined measurements shows potent accuracy in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome, thereby providing the scientific evidence for early diagnosis and stipulation of rational therapeutic regimen and improving the pregnancy outcome.

American Psychological Association (APA)

Zhang, Lin& Sun, Jin& Zhang, Ming& Lin, Yun& Le, Fang& Fang, Xiang…[et al.]. 2019. The significance of combined detection of CysC, urinary mAlb and b2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.1982-1985.
https://search.emarefa.net/detail/BIM-910133

Modern Language Association (MLA)

Zhang, Lin…[et al.]. The significance of combined detection of CysC, urinary mAlb and b2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.1982-1985.
https://search.emarefa.net/detail/BIM-910133

American Medical Association (AMA)

Zhang, Lin& Sun, Jin& Zhang, Ming& Lin, Yun& Le, Fang& Fang, Xiang…[et al.]. The significance of combined detection of CysC, urinary mAlb and b2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.1982-1985.
https://search.emarefa.net/detail/BIM-910133

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1985

Record ID

BIM-910133