Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation

Joint Authors

al-Kaladi, Ali
Afifi, Muhammad
Sadiq, Salina
Abd al-Azim, Aasir
Khatir, Safa
Ali, Haytham
Shalabi, Shayma
al-Maghribi, Umar A.

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 7 (30 Nov. 2019), pp.1436-1441, 6 p.

Publisher

Saudi Biological Society

Publication Date

2019-11-30

Country of Publication

Saudi Arabia

No. of Pages

6

Main Subjects

Biology

Topics

Abstract EN

5′ AMP-activated protein kinase (AMPK), insulin receptors and transporters are distorted in diabetes mellitus.

In this study, the effect of Panax ginseng was assessed on glucose manipulating enzymes activities and gene expression of AMPK, IRA and GLUT2 in streptozotocin-induced diabetic male rats.

Forty male albino rats were randomly divided to four groups 10 rats of each, group I, normal control group (received saline orally); group II, normal rats received 200 mg/kg of Panax ginseng orally; group III, Streptozotocin (STZ) –induced diabetic rats and group IV, STZ-induced diabetic rats received 200 mg/kg of Panax ginseng orally.

The duration of experiment was 30 days.

Results showed the ability of Panax ginseng to induce a significant decrease in the blood glucose and increase in the serum insulin levels, hepatic glucokinase (GK), and glycogen synthase (GS) activities with a modulation of lipid profile besides high expression levels of AMPK, insulin receptor A (IRA), glucose transporting protein-2 (GLUT-2) in liver of diabetic rats.

In conclusion, the obtained results point to the ability of Panax ginseng to improve the glucose metabolism in diabetic models.

American Psychological Association (APA)

Abd al-Azim, Aasir& Khatir, Safa& Ali, Haytham& Shalabi, Shayma& Afifi, Muhammad& Sadiq, Salina…[et al.]. 2019. Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1436-1441.
https://search.emarefa.net/detail/BIM-910139

Modern Language Association (MLA)

Abd al-Azim, Aasir…[et al.]. Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1436-1441.
https://search.emarefa.net/detail/BIM-910139

American Medical Association (AMA)

Abd al-Azim, Aasir& Khatir, Safa& Ali, Haytham& Shalabi, Shayma& Afifi, Muhammad& Sadiq, Salina…[et al.]. Panax ginseng improves glucose metabolism in streptozotocin-induced diabetic rats through 5′ adenosine monophosphate kinase up-regulation. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1436-1441.
https://search.emarefa.net/detail/BIM-910139

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1439-1441

Record ID

BIM-910139