Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks
Joint Authors
He, Feng
Wang, Xiying
Ren, Huimin
Sun, Laiguang
Yuan, Jian Min
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 8 (31 Dec. 2019), pp.2000-2005, 6 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Objective: To investigate the association between DD, ID and II genotypes of ACE gene and carotid stenosis, and to construct a network of ACE-related genes regulating carotid stenosis.
Approaches: Meta-analysis was used to study the association between three genotypes DD, ID and II of carotid stenosis susceptibility gene ACE; functional annotation of ACE gene was conducted by GO analysis; and a network of ACE-related genes that regulate the mechanisms of carotid stenosis was established.
Results: Meta-analysis showed that DD and II genotypes of ACE gene were associated with carotid stenosis.
GO analysis showed that the main biological processes involved in ACE include: the process of transforming angiotensinogen into mature angiotensin; angiotensin’s mediation of the brain’s response to alcohol consumption and thirst control; any chemical reaction involving the regulation of angiotensin; and the process of catalyzing the release of a C-terminal dipeptide from a polypeptide chain.
A network of ACE gene regulation of carotid stenosis was constructed in combination with KEGG analysis.
Conclusion: The ACE gene is a susceptibility gene for carotid stenosis.
Through the functional annotation and pathway analysis of ACE gene, an ACE gene-involved carotid stenosis regulatory mechanisms network was constructed.
American Psychological Association (APA)
He, Feng& Wang, Xiying& Ren, Huimin& Yuan, Jian Min& Sun, Laiguang. 2019. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182
Modern Language Association (MLA)
He, Feng…[et al.]. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182
American Medical Association (AMA)
He, Feng& Wang, Xiying& Ren, Huimin& Yuan, Jian Min& Sun, Laiguang. Association between ACE gene polymorphism and carotid stenosisand and construction of related gene regulatory networks. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2000-2005.
https://search.emarefa.net/detail/BIM-910182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2005
Record ID
BIM-910182