Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model
Joint Authors
Fan, Xiaowu
Li, Fan
Deng, Yu
Wu, Xiaowei
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 8 (31 Dec. 2019), pp.2037-2042, 6 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The purpose of this study was to explore the internal mechanism of lung cancer under the action of caspase recruitment domain-containing protein 9 (CARD9) and immunosuppressive cells myeloid-derived suppressor cells (MDSCs) in the Lewis lung cancer mice model.
In this research, mice were selected as research objects, and the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was studied by experimental methods such as mRNA expression level, HE staining of tumor cells, and electron microscopy.
The results showed that CARD9 regulated lung cancer by controlling the working state of immunosuppressive cells MDSCs and its downstream product indoleamine 2, 3-dioxygenase (IDO).
The study confirmed the tumor regulatory mechanism of CARD9-MDSCs-NF-KB-IDO in MDSCs under tumor environment.
In summary, the mechanism of CARD9 and immunosuppressive cells MDSCs in lung cancer was to achieve the goal of tumor control through the control of downstream product IDO.
There are still some shortcomings in the research process, but the research results still provide some guidance for future research.
Therefore, it is a research topic with practical significance.
American Psychological Association (APA)
Wu, Xiaowei& Li, Fan& Deng, Yu& Fan, Xiaowu. 2019. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216
Modern Language Association (MLA)
Wu, Xiaowei…[et al.]. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216
American Medical Association (AMA)
Wu, Xiaowei& Li, Fan& Deng, Yu& Fan, Xiaowu. Analysis of the control mechanism of lung cancer of caspase recruitment domain-containing protein 9 and myeloid-derived suppressor cell in Lewis lung cancer mice model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2037-2042.
https://search.emarefa.net/detail/BIM-910216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 2041-2042
Record ID
BIM-910216