Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications
Joint Authors
Krishna, Pabba Shiva
Kalyani, B. Sudha
Sreenivasulu, K.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1655-1660, 6 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Actinobacteria, which are the prolific producers of antibiotics and significant suppliers to the pharmaceutical industry, can produce a wide variety of bioactive metabolites.
An actinomycete strain designated NLKPB45 was isolated from mangrove soils samples of Nellore coastal regions Andhra Pradesh and assessed for antibiotic production and activity against pathogenic bacteria.
From a total of 9 mangrove soil samples, 143 acinomycetes were isolated.
Among the isolated them 6 actinomycetes strains showed potential antibacterial activity against at two tested pathogens gram positive and gram negative bacteria E.
coli and S.
aureus.
The potent strain NLKPB45 was identified by 16S gene isolation and sequencing to the Streptomyces genus.
The ethyl acetate extracts also as shown excellent antimicrobial activity against Salmonella sp., staphylococcus aureus, E.
coli, and B.
subtilus were detected in both the supernatant extract samples from fermentations of culture NLKPB45.
The anticancer activity of extracts in the HeLa with IC50 value of 37.1924 μg/ml, MCF-7 IC50 value of 40.9177 μg/ml and HT 29 IC50 value of 43.3758 μg/ml.
American Psychological Association (APA)
Kalyani, B. Sudha& Krishna, Pabba Shiva& Sreenivasulu, K.. 2019. Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1655-1660.
https://search.emarefa.net/detail/BIM-910290
Modern Language Association (MLA)
Kalyani, B. Sudha…[et al.]. Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1655-1660.
https://search.emarefa.net/detail/BIM-910290
American Medical Association (AMA)
Kalyani, B. Sudha& Krishna, Pabba Shiva& Sreenivasulu, K.. Screening and identification of novel isolate Streptomyces sp., NLKPB45 from Nellore costal region for its biomedical applications. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1655-1660.
https://search.emarefa.net/detail/BIM-910290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1660
Record ID
BIM-910290