Evaluation of a labdane diterpene forskolin isolated from Solena amplexicaulis (Lam.) Gandhi (Cucurbitaceae) revealed promising antidiabetic and antihyperlipidemic pharmacological properties
Joint Authors
al-Hamid, Fahd
al-Shaykh, Muhammad Sulayman
Venkatachalapathi, Arjunan
Karthika, Krishnamoorthy
Paulsamy, Subramaniyam
Thenmozhi, Krishnaswamy
Ali, Muhammad Ajmal
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1710-1715, 6 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Solena amplexicaulis (Lam.) Gandhi (Family Cucurbitaceae) is one of the important plant species used by the Irula tribes of Walayar valley of southern Western Ghats, India for the management of diabetes.
To confirm the antidiabetic property of S.
amplexicaulis, the present study was addressed using crude methanolic leaf extract of S.
amplexicaulis (MeOHSa) and its isolated compound, Forskolin against streptozotocin (STZ) induced diabetic rats.
The oral glucose tolerance test (OGTT), blood glucose, lipid profile, serum liver markers, antioxidants, hemoglobin and glycogen were evaluated using standard procedure.
The oral administration of Forskolin and MeOHSa (600 mg/kg b.w.) for 30 days resulted in significant restoration of all these parameters supported by histopathological observations too.
The results clearly suggest that the Forskolin (diterpene) possess potent antidiabetic and antihyperlipidemic activities, which may be considered as a lead molecule for therapeutic purposes, and the source of Forskolin i.e.
S.
amplexicaulis can be further exploited for pharmaceutical industries.
American Psychological Association (APA)
Venkatachalapathi, Arjunan& Thenmozhi, Krishnaswamy& Karthika, Krishnamoorthy& Ali, Muhammad Ajmal& Paulsamy, Subramaniyam& al-Hamid, Fahd…[et al.]. 2019. Evaluation of a labdane diterpene forskolin isolated from Solena amplexicaulis (Lam.) Gandhi (Cucurbitaceae) revealed promising antidiabetic and antihyperlipidemic pharmacological properties. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1710-1715.
https://search.emarefa.net/detail/BIM-910298
Modern Language Association (MLA)
Venkatachalapathi, Arjunan…[et al.]. Evaluation of a labdane diterpene forskolin isolated from Solena amplexicaulis (Lam.) Gandhi (Cucurbitaceae) revealed promising antidiabetic and antihyperlipidemic pharmacological properties. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1710-1715.
https://search.emarefa.net/detail/BIM-910298
American Medical Association (AMA)
Venkatachalapathi, Arjunan& Thenmozhi, Krishnaswamy& Karthika, Krishnamoorthy& Ali, Muhammad Ajmal& Paulsamy, Subramaniyam& al-Hamid, Fahd…[et al.]. Evaluation of a labdane diterpene forskolin isolated from Solena amplexicaulis (Lam.) Gandhi (Cucurbitaceae) revealed promising antidiabetic and antihyperlipidemic pharmacological properties. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1710-1715.
https://search.emarefa.net/detail/BIM-910298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1714-1715
Record ID
BIM-910298