TH1-TH2 chemokines-cytokines profile in rats treated with tetanus toxoid and Euphorbia tirucalli
Joint Authors
Ghramh, Hamid Ali
Kilani, Muna
Shakir, Kamil H.
al-Shahri, Muhammad
al-Sayyad, Khalid M.
al-Shahri, Ali
Kotb, Nahlah
Dajem, Sad M.
Qasim, Muhammad
al-Ahmari, Abir S.
Ibrahim, Isam H.
Mustafa, Usamah M. S.
Khan, Khalid Ali
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1716-1723, 8 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Natural products, including their purified materials, play a remarkable role in drug development.
The Euphorbiaceae family, mainly Euphorbia tirucalli, is used in some traditional medicine, and has evidence that its latex comprises immunomodulatory properties and cytokine production.
This study aimed to measure the in vivo production of chemokines (IL-1α, IL-1β, IL-12, and RANTES), TH1 cytokines (IFN-γ, TNF-α, GM-CSF, and IL-2) and TH2 cytokines (IL-4, IL-6, IL-10, and IL-13) in rats after treatments with ethanol latex extract of E.
tirucalli.
Vaccine treated and untreated rats were divided into seven groups to assess antimicrobial activities of the extracted components.
After completion of the treatment schedule, blood was withdrawn and sera were collected.
The results showed that the main component of the extract was a euphol compound.
The extract showed antimicrobial activity and had the ability to modulate innate and adaptive immunity.
Animals treated with extract for only 7 days before vaccination showed higher levels of antibody production.
The extract showed antibacterial and antifungal activities.
The extract could stimulate both adaptive and innate immunity.
Pre-treatment with the extract increased immune responses in vaccinated animals, indicating the usefulness of the extract before immunization.
American Psychological Association (APA)
Ibrahim, Isam H.& Kilani, Muna& Mustafa, Usamah M. S.& Shakir, Kamil H.& al-Shahri, Muhammad& al-Sayyad, Khalid M.…[et al.]. 2019. TH1-TH2 chemokines-cytokines profile in rats treated with tetanus toxoid and Euphorbia tirucalli. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1716-1723.
https://search.emarefa.net/detail/BIM-910299
Modern Language Association (MLA)
Ibrahim, Isam H.…[et al.]. TH1-TH2 chemokines-cytokines profile in rats treated with tetanus toxoid and Euphorbia tirucalli. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1716-1723.
https://search.emarefa.net/detail/BIM-910299
American Medical Association (AMA)
Ibrahim, Isam H.& Kilani, Muna& Mustafa, Usamah M. S.& Shakir, Kamil H.& al-Shahri, Muhammad& al-Sayyad, Khalid M.…[et al.]. TH1-TH2 chemokines-cytokines profile in rats treated with tetanus toxoid and Euphorbia tirucalli. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1716-1723.
https://search.emarefa.net/detail/BIM-910299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1723
Record ID
BIM-910299