A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces
Joint Authors
Rivera, David E.
Ocampo, Yanet C.
Castro, Jenny P.
Barrios, Lía
Diaz, Fredyc
Franco, Luis A.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1758-1766, 9 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
The use of natural products by communities from the Colombian Caribbean region to treat health issues, together with biodiversity and geographical features, constitute a great scenery to develop new therapies based on ethnopharmacological heritage.
Here, we investigated the anti-inflammatory potential of 10 commonly used plants in Colombian folk medicine, evaluating their effect on nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages.
The most active plant was evaluated in vivo using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema, along with its effect on the production of pro-inflammatory mediators in vitro.
The extract of Physalis angulata L.
calyces showed the highest activity.
This extract was fractionated and its dichloromethane fraction (DF) was the most active in vitro, inhibiting the production of NO, prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and monocyte chemotactic protein (MCP)-1 (CCL2).
In vivo, DF showed a significant inhibition of ear edema and myeloperoxidase (MPO) activity, with evident reduction of the leukocyte infiltration into tissue.
Our results support the ethnopharmacological use of the selected plants in folk medicine.
P.
angulata dichloromethane fraction represents a promising source of pharmacological compounds with great potential therapeutic use to treat inflammatory illness.
American Psychological Association (APA)
Rivera, David E.& Ocampo, Yanet C.& Castro, Jenny P.& Barrios, Lía& Diaz, Fredyc& Franco, Luis A.. 2019. A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1758-1766.
https://search.emarefa.net/detail/BIM-910305
Modern Language Association (MLA)
Rivera, David E.…[et al.]. A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1758-1766.
https://search.emarefa.net/detail/BIM-910305
American Medical Association (AMA)
Rivera, David E.& Ocampo, Yanet C.& Castro, Jenny P.& Barrios, Lía& Diaz, Fredyc& Franco, Luis A.. A screening of plants used in Colombian traditional medicine revealed the anti-inflammatory potential of Physalis angulata calyces. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1758-1766.
https://search.emarefa.net/detail/BIM-910305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1765-1766
Record ID
BIM-910305