Effect of Macrotyloma uniflorum on antiobesity in rats fed with a high fat diet

Abstract EN

Obesity is a universal health burden develops from an inequity between food consumption and energy disbursement which causes excessive deposition of fat in adipose tissue, liver tissue, muscle, pancreatic islets and other organs involved in metabolism results in dyslipidaemia, glucose intolerance, coronary heart disease, diabetes, hypertension, non-alcoholic fatty liver disease and cancer (Isabelle et al., 2017).

Globally, 600 million people are obese and 19 billion adults are overweight (Jian Bing et al., 2016).

Fat absorption process is mediated by pancreatic lipase (PL) and militarization of fat stored in adipose tissues is mediated by triglyceride lipase (TGL) (Rudolf et al., 2012).

Lifestyle modification and high energy diet have increase the incidence of obesity (Hasani et al., 2013) There are several antiobesity drugs are available, however, they have perilous side effects and hence medicinal plant including crude extracts and isolated compound from plant can be used to induce weight loss and prevent diet induced obesity (Matson and Fallon, 2012).

The potential of natural products against obesity is still largely unexplored and can be an excellent alternative for the safe and effective antiobesity drugs from natural origin.