Prediction of immune factors and signaling pathways in lung injury induced by LPS based on network analysis

Joint Authors

Wanga, Kaiwei
Zhang, Haoran
Zhang, Jiaqiang
Jia, Erju
Zhu, Guosong

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2068-2073, 6 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

6

Main Topic

Diseases
Medicine

Topics

Abstract EN

Objective: To construct a regulatory network involved in acute lung injury, so as to provide a new theoretical basis and research ideas for studying the relationship between inflammatory factors and immune proteins to collectively regulate the occurrence of acute lung injury.

Method: By using Meta-analysis, GO, KEGG and other methods notarized and constructed the regulatory network pathways of cytokine cascade and lung injury induced by LPS.

Results: The result of Meta-analysis showed that the correlation between CD14, TNF-a, IL-6 gene and acute lung injury was statistically significant.

GO analysis and KEGG analysis showed that acute lung injury contained CD14, TNF-a, IL-6 and other involved factors in the induced process of LPS, these inflammatory factors and immune proteins jointly regulate the process of disease development.

Conclusion: CD14 receptor is an important receptor involved in mediating LPS-activated cells, and is a high-affinity LPS receptor.

LPS stimulates inflammatory effector cells to bind to LPS receptor- CD14 to activate intracellular signal cascade.

Direct or indirect involvement of pathogenic factors enable cytokine caused by induction form a particularly complex network of cytokine regulatory pathways, of which the inflammatory factors TNF-a and IL-6 are simultaneously involved in LPS-mediated and CD14-mediated cytokine cascades.

American Psychological Association (APA)

Wanga, Kaiwei& Zhang, Haoran& Zhang, Jiaqiang& Jia, Erju& Zhu, Guosong. 2019. Prediction of immune factors and signaling pathways in lung injury induced by LPS based on network analysis. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2068-2073.
https://search.emarefa.net/detail/BIM-910407

Modern Language Association (MLA)

Wanga, Kaiwei…[et al.]. Prediction of immune factors and signaling pathways in lung injury induced by LPS based on network analysis. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2068-2073.
https://search.emarefa.net/detail/BIM-910407

American Medical Association (AMA)

Wanga, Kaiwei& Zhang, Haoran& Zhang, Jiaqiang& Jia, Erju& Zhu, Guosong. Prediction of immune factors and signaling pathways in lung injury induced by LPS based on network analysis. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2068-2073.
https://search.emarefa.net/detail/BIM-910407

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2073

Record ID

BIM-910407