Influence of olive leaves extract on hepatorenal injury in streptozotocin diabetic rats
Joint Authors
al-Salmi, Fawziyah A.
al-Attar, Atif M.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1865-1874, 10 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
Medicinal plants have always been an important source of new alternative effective compounds for human therapy.
Currently, there are many of scientific evidences indicate that the medicinal plants contain a lot of hypoglycemic chemical compounds.
The purpose of the present study was to determine the influence of olive leaves extract on hepatorenal injury in diabetic male rats.
Experimental diabetes was induced by streptozotocin (STZ).
The levels of serum glucose, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen, uric acid and malondialdehyde were significantly increased, while the levels of serum superoxide dismutase, glutathione and catalase were statistically decreased in untreated diabetic rats.
Moreover, the histopathological examination showed several alterations in the structure of liver and kidney in untreated diabetic rats.
Treatments with low dose and high dose of olive leaves extract in diabetic rats showed remarkable reducing and protecting influences of physiological and histopathological alterations.
Moreover, the highly treatment efficiency was noted in diabetic rats treated with high dose followed by low dose of olive leaves extract.
Additionally, the results of this study proved that the antioxidant activities of olive leaves extract played a vital role against the hepatorenal injury induced by diabetes.
Finally, this study indicates to the importance of the use of olive leaves extract as promising alternative and complementary therapeutic agent against diabetes and its complications.
American Psychological Association (APA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. 2019. Influence of olive leaves extract on hepatorenal injury in streptozotocin diabetic rats. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1865-1874.
https://search.emarefa.net/detail/BIM-910435
Modern Language Association (MLA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. Influence of olive leaves extract on hepatorenal injury in streptozotocin diabetic rats. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1865-1874.
https://search.emarefa.net/detail/BIM-910435
American Medical Association (AMA)
al-Attar, Atif M.& al-Salmi, Fawziyah A.. Influence of olive leaves extract on hepatorenal injury in streptozotocin diabetic rats. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1865-1874.
https://search.emarefa.net/detail/BIM-910435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1873-1874
Record ID
BIM-910435