Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice
Joint Authors
Saggu, Shalini
Zaydan, Nahlah
Rahman, Hasibur
Trivedi, Subrata
al-Thbiani, Aziz
al-Zibr, Fahad M. A.
Abd al-Wahhab, Atif
Oyouni, A.
Panneerselvam, Chellasamy
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 7 (30 Nov. 2019), pp.1875-1881, 7 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Cadmium is among the toxic and hazardous metal widely dispersed in the environment in high levels.
Current studies have provided new insights into antioxidant properties of bioflavonoid which have emerged as probable therapeutic and nutraceutical agents.
The present study is geared to investigate the possible role of Cymbopogon schoenanthus (L.) Spreng.
(or Ethkher) on heavy metal cadmium (Cd) induced oxidative stress in mice.
Mice were randomly divided into four groups and treated for 15 days as follows: group 1: normal control-treated (saline); group 2: Ethkher leaves extract-treated (100 mg/kg); group 3: cadmium chloride (CdCl2) treated; group 4: CdCl2 plus Ethkher leaves extract.
The results showed a significant reduction in hemoglobin, RBC and hematocrit in cadmium-treated mice as compared to control.
Exposure to Cd caused a significant increase in the number of white blood cells (P < 0.05) indicating the occurrence of systemic inflammation.
The results of this study also revealed that the mice intoxicated with Cd showed a significant increase in bilirubin, aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGTP) activities.
Cd intoxication leads to suppression in humoral immunity.
However, pretreatment with Ethkher extract reversed almost all the abnormalities in the blood parameters showing noteworthy protection against cadmium induced toxicity in mice.
The outcome of the present study revealed that the Ethkher possessed significant immunomodulatory activity and had a preventive effect on the hematological alterations in Cd intoxicated mice.
American Psychological Association (APA)
Saggu, Shalini& Rahman, Hasibur& al-Thbiani, Aziz& al-Zibr, Fahad M. A.& Abd al-Wahhab, Atif& Oyouni, A.…[et al.]. 2019. Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice. Saudi Journal of Biological Sciences،Vol. 26, no. 7, pp.1875-1881.
https://search.emarefa.net/detail/BIM-910436
Modern Language Association (MLA)
Saggu, Shalini…[et al.]. Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice. Saudi Journal of Biological Sciences Vol. 26, no. 7 (Nov. 2019), pp.1875-1881.
https://search.emarefa.net/detail/BIM-910436
American Medical Association (AMA)
Saggu, Shalini& Rahman, Hasibur& al-Thbiani, Aziz& al-Zibr, Fahad M. A.& Abd al-Wahhab, Atif& Oyouni, A.…[et al.]. Cymbopogon schoenanthus (Ethkher) ameliorates cadmium induced toxicity in swiss albino mice. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 7, pp.1875-1881.
https://search.emarefa.net/detail/BIM-910436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1880-1881
Record ID
BIM-910436