Construction of rat spinal cord injury model based on Allen’s animal model

Joint Authors

Li, Shuliang
Ma, Jingjian
Wang, Dong
Zhou, Jiangbo
Zhang, Jianjun

Source

Saudi Journal of Biological Sciences

Issue

Vol. 26, Issue 8 (31 Dec. 2019), pp.2122-2126, 5 p.

Publisher

Saudi Biological Society

Publication Date

2019-12-31

Country of Publication

Saudi Arabia

No. of Pages

5

Main Topic

Diseases
Medicine

Topics

Abstract EN

The aim of this study is to explore the construction of rat spinal cord injury model guided by Allen’s model.

Methods: Male rats aged 4–5 weeks and weighing about 250 g are selected as subjects in the Animal Laboratory Center of XX Hospital.

Rats are divided into two groups, which are experimental group 1 and experimental group 2, respectively, so as to construct spinal cord injury model in rats.

The first group is given 300 g.cm hitting force of T10 spinal cord, and the second group is given 500 g.cm hitting force of T10 spinal cord.

Within 25 days after spinal cord injury in Allen’s rats, the survival, neurological function, diet, motor ability, tactile ability and auditory ability of the two groups are monitored and evaluated daily.

Results: In terms of survival, the survival rate of rats in group 1 is 85%, while that of rats in group 2 is 21%, and there is a concentrated death phenomenon in group 2.

In terms of neurological function recovery, experimental group 1 is stable and gets 7 points and experimental group 2 is stable and gets 3 points.

In terms of diet, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points.

In terms of motor ability, the experimental group 1 is stable and gets 5 points and the experimental group 2 is stable and gets 2 points.

In tactile sense, experimental group 1 is stable and gets 17 points and experimental group 2 is stable and gets 12 points.

It can be seen that the post-operative recovery ability of the experimental group 1 is better than that of the experimental group 2.

Conclusion: Under the guidance of Allen’s model, compared with the group 2, the experimental group 1 of the rat spinal cord injury model has better recovery in each index.

It can be seen that the smaller impact strength is more beneficial to the recovery of rats after spinal cord injury surgery.

American Psychological Association (APA)

Li, Shuliang& Zhou, Jiangbo& Zhang, Jianjun& Wang, Dong& Ma, Jingjian. 2019. Construction of rat spinal cord injury model based on Allen’s animal model. Saudi Journal of Biological Sciences،Vol. 26, no. 8, pp.2122-2126.
https://search.emarefa.net/detail/BIM-910630

Modern Language Association (MLA)

Li, Shuliang…[et al.]. Construction of rat spinal cord injury model based on Allen’s animal model. Saudi Journal of Biological Sciences Vol. 26, no. 8 (Dec. 2019), pp.2122-2126.
https://search.emarefa.net/detail/BIM-910630

American Medical Association (AMA)

Li, Shuliang& Zhou, Jiangbo& Zhang, Jianjun& Wang, Dong& Ma, Jingjian. Construction of rat spinal cord injury model based on Allen’s animal model. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 8, pp.2122-2126.
https://search.emarefa.net/detail/BIM-910630

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 2126

Record ID

BIM-910630