Epithelial mesenchymal transition (EMT)‎ -associated S100 proteins are modulators for the progression of bladder cancer

Abstract EN

Bladder cancer (BC) is considered to be the tenth in the world.

There is much evidence to suggest that the highly metastatic behaviour of BC may be due to the ability of its cells to undergo Epithelial Mesenchymal Transition (EMT).

The S100 family of small Ca-binding proteins are among many genes that have been found to be implicated in BC cancer progression.

Activation of some members of the S100 protein family, such as S100A4 and S100A6, have been postulated to be a common mediator of the EMT process and a key driver for cancer cell migration and invasion.

To our knowledge, however, there is no conclusive evidence that the presence of the S100 family is causally implicated in EMT-induced BC progression.