A study effect of iron overload on thyroid gland and other tissues in thalassemia patients in Najaf City

Abstract EN

This study highlights the effects of iron overload on endocrine glands (Thyroid gland), kidney functions and liver functions in thalassemia patients in Najaf province in Iraq.

One hundred patients suffering from thalassemia were contributed in the current study.

Their age range was 3-18 years old.

Thirty apparently healthy person were nominated as "control group".

Serum iron , liver functions test (AST,ALT,ALP,TSB) and Kidney functions test (Uera& Creatinine) were measured spectrophotometrically while Serum ferritin, was measured using ELISA, Thyroid hormones (T3 & T4) estimation by Using(I-Chroma instrument) The results indicated significant increase (p<0.05) in iron , ferritin and TSB in patients in comparing with healthy control group while liver functions test (AST,ALT,ALP ) and Kidney functions test (Uera& Creatinin) were no significant.

We conclude from this study that Thalassemia patients in Najaf city are exposed to the risk of overload and the risk of oxidation.

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thalassmic patients are susceptible to tissue damage produced by "oxidative stress".

There is no statistically significant correlation noticed between each serum AST,ALT,TSB, Uera and Creatinin with iron status The reason is that these patients continue treatment(Defroxamin) that reduces iron levels in their bodies