Formulation and evaluation of floating microspheres of clarithromycin

Abstract EN

In this work we prepare, characterize and evaluatefloating microspheres of Clarithromycinby ionic gelation method with an aim of increasing the gastric residence time and for controlled release.Gelatin, polymeric mixture of gelatin and Hydroxy ethyl cellulose (HEC) were used as polymers.

Sodium bicarbonate was used as the gas-forming agent.

The production microspheres were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and photomicrographs microscopy.

The prepared floating microspheres evaluated by particles size distribution, floating behavior, drug content, entrapment efficency, morphology and in vitro release werestudied.The micros pheres diameters range322.49μm-584.64 μm.The results the release rate decrease with increaseing coeting material concentration.

The floating microspheres followed zero order kinetics and drug mechanisam releasedtoPeppas model.

The microspheres exponential coefficient values between 0.559 and 0.911 that indicatied to non fickian diffusion controlled release mechanism.