دراسة العلاقة بين تعدد الأشكال الوراثية لجينات (CD28+IVS3 17T C)‎ و (CTLA-4+49A G)‎ و اضطربات المناعة الذاتية للغدة الدرقية في محافظة ذي قار-العراق

Abstract EN

This study has been designed to investigate the role of the (CD28IVS3+17C/T , CTLA- 4+49A/G ) genes Polymorphisms and the extent to which they contribution in thyroid autoimmune disorders at Thi- Qar Province.

The current study included 240 people and who were among the three groups by 80 people in each group.

The first group (patients with hyperthyroidism ), the second group (patients with hypothyroidism) and third group are (healthy group) with no infection of any disease of the thyroid gland .

DNA was extracted from the two groups of patients and the healthy group and then amplified genes (CD28, CTLA-4) using PCR technique.

The RFLP technique used to detect the CD28IVS3+17C/T , CTLA-4+49A/G genes Polymorphisms .

The results of the present study showed that there was no association between gene Polymorphisms (CD28 + IVS3 17T) and thyroid autoimmune disorders.

On the other hand, the results of the study showed a correlation between the CTLA-4+49A/G gene Polymorphisms and autoimmune disorders of the thyroid gland in patients compared to the healthy group.

The risk of hyperthyroidism is two time at the heterozygous (A/G ) in patients compared to the healthy group ( OR=2.09;95% CI=0.946 – 4.624) , and four time at the homozygous (G/G ) in patients compared to the healthy group ( OR=4.11;95% CI=1.888 – 8.8.951).

The risk of hypothyroidism was one and a half time at the heterozygous (A/G ) in patients compared to the healthy group ( OR=1.52;95% CI=0.701 – 3.329), and It is three times the presence of the heterozygous (G / G) in patients compared to the healthy group( OR=3.03;95% CI=1.415 – 6.456).