Effect of aqueous extract of Rosmarinus officinalis on kidney and liver of male rats experimentally infected with diabetic

Abstract EN

The present study was designed to investigate the effect of aqueous extract of rosemary on some organs such as kidney and liver of diabetic rats .

Twenty eight adult male albino rats were equally divided into four groups ; the first group gulped with distilled water which consider as the control group .The second group administered the aqueous extract of rosemary , The third group experimentally diabetic by alloxan that induced many histological changes in the kidney and liver while the fourth group diabetic and treated with aqueous extract of rosemary .

Histological changes were observed in kidney which included contraction of glomeruli , enlargement of space Bowman's capsule , degeneration and necrosis of renal tubules , haemorrhage , absence of glomeruli , aggregation inflammatory cells , degenerative and necrosis of glomeruli , then the histological changes was advanced to arrival to death of glomerulus , perfect closed to canal of renal tubules , hyperplasia and venous congestion .

Diabetic caused in liver some histological changes as aggregation inflammatory cells , edema in central vein , necrosis , degeneration of hepatocytes, haemorrhage , enlargement of sinusoids , congestion of the central portal vein , vacuolation of hepatocytes and fibrosis .

Histopathological examination of the rat's organs confirmed this amelioration of health showing that using of aqueous extract of rosemary can reduce pathological changes in kidney and liver .

This study clearly demonstrated that administration of aqueous extract of rosemary alleviates the harmful effects of diabetic induced kidney and liver damages .