Identification histopathological characterizations of mercuric chloride toxicity in albino male mice

Abstract EN

Mercury compounds have been known as one of most heavy metals which cause adverse effect for both human and animal.

Nevertheless, several studies have been documented poison effect of mercury in different aspects, but so far there are few reports related histopathlogical changes are not enough clear according dose-dependent.

Therefore, our study focused on histopathlogical examination of kidney and lung tissues which were treated with two different dose of mercuric chloride to elucidate level of toxicity.

Thirty male mice have been equally divided in to three groups.

First group was treated with distilled water as control and other two groups were given two different doses of mercuric chloride; 1mg\k.g and 4 mg\k.g respectively.

All animals have been administrated by intra-peritoneal injection for 60 consecutive days.

At the end of experimental; all mice were sacrificed and eviscerated the target organs (kidney and lung) to prepare for histological processing steps.

Histopathlogical results have revealed that severity of low dose mercuric chloride administration was minor effect than high dose given in both kidney and lung.

That was showing moderate renal structures damages and pulmonary parenchyma destruction.

Consequently, these results indicated that toxic activity of mercuric chloride was according to dose-dependent.

Subsequently, the moderate damages have been occurred in renal and lung tissues due to long term exposure.