Comparing the effect of lidocaine-magnesium sulfate combination with amiodarone-magnesium sulfate combination in preventing ventricular fibrillation after aortic artery cross-clamp removal during coronary artery bypass graft surgery
Joint Authors
Jarineshin, Hashim
Kashani, Said
Fekrat, Fereydoon
Shahdadi, Maryam Muradi
Shahabadi, Nada Sultani
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 5 (31 May. 2018), pp.1-11, 11 p.
Publisher
Publication Date
2018-05-31
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Topics
Abstract EN
Background: The prevalence of ventricular fibrillation after removal of the aortic cross - clamp in patients undergoing coronary artery bypass surgery is about 74% - 96%.
Defibrillation shock and different types of agents are used to treat ventricular fibrillation (VF).
Objectives: This study was aimed to compare the effects of combining Lidocaine + Magnesium Sulfate with Amiodarone + Magnesium Sulfate in the prevention of reperfusion - induced ventricular fibrillation.
Methods: This randomized, double- blinded clinical study included 74 ASA class II and III patients undergoing coronary artery bypass grafting (CABG) in a university - affiliated hospital, Bandar Abbas, Iran, in the years 2015 - 2016.
Patients were divided into two groups based on a random sample table of the lock.
Both groups received Magnesium Sulfate through the cardiopulmonary bypass pump.
Lidocaine 2% (100 mg) and Amiodarone (300 mg) were injected respectively to group Lidocaine + Magnesium Sulfate (LM) and group Amiodarone + Magnesium Sulfate (AM) patients before aortic cross - clamp release.
The incidences of arrhythmias were recorded within 30 minutes after release of the aortic cross - clamp (ACC).
Additionally, the defibrillation shocks (frequency and level of Joules delivered), amount of inotrope agent, and the hemodynamic and arterial blood gas parameters were recorded up to 24 hours postoperatively.
Results: There was no significant difference between the two groups in terms of demographic characteristics, ejection fraction, and ASA class.
The prevalence of ventricular fibrillation (VF) and atrial fibrillation (Af) 30 minutes after ACC release were 46.7% and 53.3% (P = 0.240) vs.
33.3% and 66.7% (P > 0.999); while, up to 24 hours post - operatively were 60% and 20.0% vs.
0.0% and 0.0% in groups LM and AM respectively.
The number of defibrillations in the Lidocaine + Magnesium Sulfate group was significantly higher; 57.9% vs.
25% in groups LM and AM respectively (P = 0.004).
Conclusions: The use of Amiodarone + Magnesium Sulfate reduces the number of defibrillation following the release of the Aortic cross - clamp compared with Lidocaine + Magnesium Sulfate.
American Psychological Association (APA)
Kashani, Said& Jarineshin, Hashim& Fekrat, Fereydoon& Shahdadi, Maryam Muradi& Shahabadi, Nada Sultani. 2018. Comparing the effect of lidocaine-magnesium sulfate combination with amiodarone-magnesium sulfate combination in preventing ventricular fibrillation after aortic artery cross-clamp removal during coronary artery bypass graft surgery. Iranian Red Crescent Medical Journal،Vol. 20, no. 5, pp.1-11.
https://search.emarefa.net/detail/BIM-912211
Modern Language Association (MLA)
Kashani, Said…[et al.]. Comparing the effect of lidocaine-magnesium sulfate combination with amiodarone-magnesium sulfate combination in preventing ventricular fibrillation after aortic artery cross-clamp removal during coronary artery bypass graft surgery. Iranian Red Crescent Medical Journal Vol. 20, no. 5 (May. 2018), pp.1-11.
https://search.emarefa.net/detail/BIM-912211
American Medical Association (AMA)
Kashani, Said& Jarineshin, Hashim& Fekrat, Fereydoon& Shahdadi, Maryam Muradi& Shahabadi, Nada Sultani. Comparing the effect of lidocaine-magnesium sulfate combination with amiodarone-magnesium sulfate combination in preventing ventricular fibrillation after aortic artery cross-clamp removal during coronary artery bypass graft surgery. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 5, pp.1-11.
https://search.emarefa.net/detail/BIM-912211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p.10-11
Record ID
BIM-912211