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Celery plus anise versus metformin for treatment of Oligomenorrhea in polycystic ovary syndrome : a triple-blind, randomized clinical trial
Joint Authors
Hamdi, Kobra
Fazljou, Sayyid Muhammad Baqir
Tansaz, Mojgan
Jazani, Arezoo Moini
Azgomi, Ramin Nasimi Doost
Bazargani, Homayoun Sadiqi
Nazimiyah, Husayn
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 5 (31 May. 2018), pp.1-11, 11 p.
Publisher
Publication Date
2018-05-31
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Topics
Abstract EN
Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women.
Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles.
Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) and metformin (met.) on oligomenorrhea in PCOS patients.
Methods:We conducted a triple-blind, Randomized clinical trial on 72 patients that were randomly allocated into two equal groups to receive six capsules of either CAC (750mgeach) or met.
(250mgeach) at three separate doses for 15 days beginning from the follicular phase.
If the bleeding occurred, three capsules of either placebo or met.
would be administered daily during the menstruation phase, and then the follicular phase step with six capsules would be repeated.
If the bleeding did not occur, three capsules of either placebo or met.
would be administered each day for 15 days.
The regularity of menstrual bleeding as the primary outcome, as well as testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications, was assessed before and after the three cycles.
Results: The mean agestandard deviation of patients was 26.56.1.
The mean Body Mass Index was 26.43.5.
CAC significantly improved oligomenorrhea (58.3% vs.
25%, P < 0.01), increased bleeding episodes (P = 0.003), and reduced testosterone (mean difference: 0.16 vs.
-0.02, P = 0.005) and LH/FSH (mean difference: 0.75 vs.
-0.08, P = 0.002) without any major side effects compared to met.
Conclusions:We showed that Celery and Anise combination could regulate menstrual cycles and improve oligomenorrhea in polycystic ovary syndrome patients superiorly to metformin.
American Psychological Association (APA)
Jazani, Arezoo Moini& Nazimiyah, Husayn& Tansaz, Mojgan& Bazargani, Homayoun Sadiqi& Fazljou, Sayyid Muhammad Baqir& Azgomi, Ramin Nasimi Doost…[et al.]. 2018. Celery plus anise versus metformin for treatment of Oligomenorrhea in polycystic ovary syndrome : a triple-blind, randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 5, pp.1-11.
https://search.emarefa.net/detail/BIM-912264
Modern Language Association (MLA)
Jazani, Arezoo Moini…[et al.]. Celery plus anise versus metformin for treatment of Oligomenorrhea in polycystic ovary syndrome : a triple-blind, randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 5 (May. 2018), pp.1-11.
https://search.emarefa.net/detail/BIM-912264
American Medical Association (AMA)
Jazani, Arezoo Moini& Nazimiyah, Husayn& Tansaz, Mojgan& Bazargani, Homayoun Sadiqi& Fazljou, Sayyid Muhammad Baqir& Azgomi, Ramin Nasimi Doost…[et al.]. Celery plus anise versus metformin for treatment of Oligomenorrhea in polycystic ovary syndrome : a triple-blind, randomized clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 5, pp.1-11.
https://search.emarefa.net/detail/BIM-912264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-11
Record ID
BIM-912264