Curative effects of gum Arabic and Boswellia species on acute renal failure in experimental rats

Abstract EN

Acute renal failure (ARF) was induced by glyc-erol or paracetamol in experimental rats to evalu-ate the curative effects of gum Arabic and Boswel-lia sp.

through different blood biochemical assays and hematological analyses.

Results revealed presence of significant (P<0.05) increases in the levels of urea, creatinine, potassium (K+), sodium (Na+), chloride (Cl-) and blood acidity (H+), and significant (P<0.05) decreases in the levels of cal-cium (Ca+2) and bicarbonate (HCO3-) in the rats treated only with glycerol or paracetamol in the positive control groups compared to the negative control group.

These results indicated that glycerol or paracetamol caused ARF in these groups of rats whereas the blood analyses illustrated ARF symp-toms such as increasing of urea and creatinine, hyperkalemia, hypocalcemia, hypoglycemia, blood acidosis and anemia occurring in the positive con-trol groups.

The blood analyses also illustrated recovery of these symptoms in the treated rats with gum Arabic and Boswellia sp.

in drinking water (10% w/v) for 30 days.

This indicated the curative effects of gum Arabic and Boswellia sp.

against ARF induced by glycerol or paracetamol as evi-denced by restoring the kidney function tests such as urea, creatinine, blood electrolytes and other parameters like serum glucose, proteins and he-matological indices to their normal values during the experiment period.

The therapeutic effects of both plants against ARF may be due to their anti-oxidant and/or anti-inflammatory activity