Evaluation the pathogenecity of campylobacterjejuni hepatic toxin
Joint Authors
Abbas, Ala Fahim
al-Dhahab, Azhar Umran Latif
Source
Journal of al-Qadisiyah for Pure Science
Issue
Vol. 23, Issue 3 (30 Sep. 2018), pp.148-156, 9 p.
Publisher
al-Qadisiyah University College of Science
Publication Date
2018-09-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
The current study investigated the gene responsible of hepatic toxin in Campylobacter jejuniisolatesthat isolated from children suffering diarrhea using polymerase chain reaction technique (PCR).
The results showed that only one C.
jejuni isolate that obtained from watery diarrheal stool was carrying hepatic toxin gene.
Hepatic toxin was extracted fromproducedC.jejuniisolateand tested its effectiveness by liver function test in Swiss mice female type Balb/c (Mus musculus).
The intravenous injection of 100 μg / 0.5 ml of hepatic toxin extract led to a significant increase in the mean concentration of liver enzymes Glutamate oxaloacetate transaminase (GOT) and Glutamate pyruvate transaminase (GPT), while the increase was not significant in mean concentration of the enzyme Alkaline phosphatase (ALP) compared with the control mice.
In addition, histopathological study showed that hepatic toxinextracthad severe effects represented by multiple foci of inflammatory cells, bloody congestion, and necrosis in liver, hemorrhage and penetration of inflammatory cells in the spleen, while no histological changes was induced by hepatic toxin extract in the intestine.
American Psychological Association (APA)
Abbas, Ala Fahim& al-Dhahab, Azhar Umran Latif. 2018. Evaluation the pathogenecity of campylobacterjejuni hepatic toxin. Journal of al-Qadisiyah for Pure Science،Vol. 23, no. 3, pp.148-156.
https://search.emarefa.net/detail/BIM-913360
Modern Language Association (MLA)
Abbas, Ala Fahim& al-Dhahab, Azhar Umran Latif. Evaluation the pathogenecity of campylobacterjejuni hepatic toxin. Journal of al-Qadisiyah for Pure Science Vol. 23, no. 3 (2018), pp.148-156.
https://search.emarefa.net/detail/BIM-913360
American Medical Association (AMA)
Abbas, Ala Fahim& al-Dhahab, Azhar Umran Latif. Evaluation the pathogenecity of campylobacterjejuni hepatic toxin. Journal of al-Qadisiyah for Pure Science. 2018. Vol. 23, no. 3, pp.148-156.
https://search.emarefa.net/detail/BIM-913360
Data Type
Journal Articles
Language
English
Record ID
BIM-913360