Synthesis and characterization some novel heterocyclic compounds of pyrimidine and pyrazole from chalcone derivatives

Abstract EN

In this article, several novel heterocyclic derivatives, for example, chalcone, Pyrazoles, and pyrimidine were synthesized by reaction 2,3-dichlorobenzaldehyde with paracetamol utilizing KOH as a catalyst to shape 3-(2, 3-Dichloro-phenyl)-N-(4-hydroxy-phenyl)-acrylamide (1).the compound (1) on interact with urea, Thiourea in the existence of KOH and methanol as a catalyst give 4-(2, 3-Dichloro-phenyl)-6-(4-hydroxy-phenylamino)-pyrimidin-2-ol (2) and 4-[6-(2, 3-Dichloro-phenyl)-2-mercapto-pyrimidin-4-ylamino]-phenol (3) individually.

when compound (1) responding with hydrazine monohydrate in the existence of acetic acid as a stimulant substance it will give 4-[5-(2, 3-Dichloro-phenyl)-1H-pyrazol-3-ylamino]-phenol (4).

all synthesized compounds have been distinguished by TLC, IR, 1H.NMR and 13C NMR spectroscopy.