Grape seed extract role against carbimazole action on thyroid gland and lipid profile in male rats

Abstract EN

Results showed that the animals treated with carbimazole had a significant decrease(P<0.05) in the concentration of thyroid hormones and increase TSH compared with their normal range level in the control group and the rest of the experimental groups, While groups in which grape seed extract(GSE) interferes with drug showed improvement in thyroid hormones level closer to normal range in control group.

Also the results showed significant increase (P<0.05) in TC, TG HDL, vLDL and significant decrease in LDL in carbimazole group, in addition to damage in thyroid tissue.

On the other hand animals treated by both grape seed extract (GSE) and drug showed significant improvement(P<0.05) in TC, TG, HDL, vLDL, LDL and thyroid tissue compared with groups treated with drug only.

It was concluded from this study that grape seeds extract had protective role against damage caused by carbimazole.